DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and Ugt8

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_062149.1	Gene:	Ugt8 / 50555	RGDID:	3938	Length:	541	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	156/555 - (28%)
Similarity:	268/555 - (48%)	Gaps:	82/555 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRTFTLILGLLCS-LGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAG-HTITVVSVFPQKKPI 63
            |:::|....||.| :|.:.....::|......||..:...||..|.:.| ||:.::|......|.
  Rat     1 MKSYTPYFMLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVFLLSEGRDIDPS 65

  Fly    64 PGYTDVSVPNVIEVMGGDIGALWASIQKTYTQNL--------IDHYQMGFRITRGLFEDSNFQDF 120
            ..|:....|.:......| ..|.:.::..::..|        :|||      |:..       |.
  Rat    66 NHYSLQRYPGIFNSTTSD-AFLQSKMRNIFSGRLTAVELVDILDHY------TKNC-------DM 116

  Fly   121 LKSNQS---------FDAIICETFYNDAHYGLAEHFNAPLIGL---ATGGGLTFITDMVGSPAPA 173
            :..||:         ||.::.:.  ||    :.....|.|:|:   ....||.:..: ||:|||.
  Rat   117 MVGNQALIQGLKKEKFDLLLVDP--ND----MCGFVIAHLLGVKYAVFSTGLWYPAE-VGAPAPL 174

  Fly   174 SFVPHIMLPFNDHMSLYERLLN----------VAFL---GYERVLLDYYFLPTQEKLYKEFFPGN 225
            ::||.......|.|:..||:.|          |:||   .|||::..|..||.
  Rat   175 AYVPEFNSLLTDRMNFLERMKNTGVYLISRMGVSFLVLPKYERIMQKYNLLPA------------ 227

  Fly   226 KRCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFIN-ESEHGAIY 289
             :..|.:...:||.::...|:|.||||..||::.|||: :....:||||.::|::: ..|||.:.
  Rat   228 -KSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGI-LTKPASPLPEDLQRWVDGAQEHGFVL 290

  Fly   290 FSMGSNLK--TKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPK 352
            .|.|:.:|  ::|:    ..::..|||.|.|:|:|:|......|...|..:.:|.||.|:|.|..
  Rat   291 VSFGAGVKYLSEDI----ANKLAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSN 351

  Fly   353 IMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERI 417
            |.||::|||:.|..|::||..||:|:|:|.|.:..|...:..|.||:|::.|:...|...|:.::
  Rat   352 IRAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKV 416

  Fly   418 TSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLII 482
            .:.|||.:..|.:|..::||...|:....||::::.||.||.:|:||..::::.||..:|:..::
  Rat   417 INNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGAHHLRSAVHQISFCQYFLLDIAFVL 481

  Fly   483 FV-VMVLLLIVLPIT--IYKLLKKLLLKGERTQST 514
            .: .:.|..||..:|  ||:.:|.|..:.  |.||
  Rat   482 LLGAVALYFIVSYVTKFIYRKVKSLCSRS--THST 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	145/516 (28%)
Ugt8	NP_062149.1	egt	8..490	CDD:223071	144/520 (28%)
Ugt8	NP_062149.1	UDPGT	21..502	CDD:278624	145/519 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344193
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.740