DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and RGD1559459

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_003751392.1	Gene:	RGD1559459 / 501907	RGDID:	1559459	Length:	530	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	167/544 - (30%)
Similarity:	256/544 - (47%)	Gaps:	72/544 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRTFTLILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPG 65
            |....|:|.|....|..||...|:.  ....||:.....:...|||.||.:.|:      ||...
  Rat     5 MTAALLLLHLTIFFGSGSGGKVLVW--PVEFSHWLNLKIILSELVKKGHEVVVL------KPSVS 61

  Fly    66 YT-DVSVPNVIEVMG-------GDIGALW-----ASIQKTYTQNLIDHYQMGFRITRGLFE---- 113
            :: :|...:.||...       .|:..::     .||.:...|:...::.|    .:.|||
  Rat    62 FSYEVDKTSAIEFESFPSSYSIADVEVIFMDCVNESIYELPKQSFWGYFLM----LQKLFERTSD 122

  Fly   114 -------DSNFQDFLKS---NQSFDAIICETF--YNDAHYGLAEHFNAPLI-GLATGGGLTFITD 165
                   |:.|...|.:   |..||.|:.:.|  ..|.   |||....||: .|....|.|:...
  Rat   123 YSERLCRDAAFNKELMTKLQNSGFDVILADPFTPCGDL---LAEILKIPLVYSLRFFPGSTYEKY 184

  Fly   166 MVGSPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFP---GNKR 227
            ..|.|.|.|:||..|...:|.|:..||:.::.::    :..|::|....||.:.|.:.   |...
  Rat   185 SGGLPMPPSYVPIAMSELSDRMTFVERVKHMIYV----LCFDFWFQVFDEKKWNELYTEVLGRPT 245

  Fly   228 CFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFS 291
            ...:....|.:.||..:..|.||.|..||...|||:|.... .|||::||.|:..| |||.:.||
  Rat   246 TLSETMAKADIWLIRTYWDLEFPHPVLPNFDFVGGLHCRPA-KPLPKEIEDFVQSSGEHGVVVFS 309

  Fly   292 MGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPE----NVYISDWFPQTDILAHPK 352
            :||.:.:  |...:...|...|..:.|:|||:||    ..|||    |..:..|.||.|:|.|||
  Rat   310 LGSMVGS--LTEERANVIAAGLAQIPQKVLWRFE----GKKPETLGSNTRLYKWIPQNDLLGHPK 368

  Fly   353 IMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERI 417
            ..||:||||.....|:|||..||:|:|:|.||..|:.|.:..|..:.|||.|:::.:...|:..:
  Rat   369 TRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQKDNIVHLKTKGAAVRLDFLTMSSTDLLTALRTV 433

  Fly   418 TSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLII 482
            |::|||.:....:|..:.||...|::.|::|:|.|.||:||.:|:.|...|:|.|||::||
  Rat   434 TNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAGHDLSWVQYHSLDV---- 494

  Fly   483 FVVMVLLLIVLPITIYKLLKKLLL 506
                :..|:...:|:..:|||..|
  Rat   495 ----IGFLLACVVTVMFILKKCCL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	161/516 (31%)
RGD1559459	XP_003751392.1	UDPGT	24..527	CDD:278624	160/525 (30%)
RGD1559459	XP_003751392.1	egt	<270..508	CDD:223071	94/252 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344109
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690