DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt1ab

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_998587.2	Gene:	ugt1ab / 406731	ZFINID:	ZDB-GENE-040426-2762	Length:	536	Species:	Danio rerio

Alignment Length:	533	Identity:	146/533 - (27%)
Similarity:	254/533 - (47%)	Gaps:	42/533 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FTLILGL---LCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPG 65
            |...|||   ||.....|.....:::.....||:.....|.:.:...||.:.|  :.|:...:.|
Zfish    16 FVPALGLFAFLCLFSSESVQAGKVLVMPVDGSHWLSMKILVEEMSSRGHEMVV--LVPETSILIG 78

  Fly    66 ----YTDVS--VPNVIEVMGGDIGALWASIQKTYTQ-------------NLIDHYQMGFRITRGL 111
                :|..|  ||...:.:...:.    .|:||..:             |||....|..:...||
Zfish    79 KSGNFTTKSFRVPYSFDELNAHVD----HIRKTAIEKAPRFIDIVGALGNLIQFTNMQVKACEGL 139

  Fly   112 FEDSNFQDFLKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGSPAPASFV 176
            ..|......|: :..|||::.:.|...... :|::|:.|.:....|............|:|.||:
Zfish   140 LYDEPLMKSLR-DMKFDALLTDPFLPCGSV-IADYFSIPAVYFLRGIPCRLDEAAAQCPSPPSFI 202

  Fly   177 PHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRRNASLVLI 241
            |.....:.|.|:..:|::|.....:|:.|....|....|...:  :......:.::..:.::.|:
Zfish   203 PRFFTGYTDKMTFPQRMINTFMTVFEKYLCHQLFASFDELATR--YLKKDTSYAELLGHGAVWLL 265

  Fly   242 NQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKDLPPSK 305
            ....|..:|:|..|||:::||::. .|..||.:::|.|:|.| |||.:.|::||  ....||.:|
Zfish   266 RYDFSFEYPKPQMPNMVQIGGINC-AKRAPLTKELEEFVNGSGEHGFVVFTLGS--MVSQLPEAK 327

  Fly   306 VQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESIY 370
            .:|..:|...:.|||||::......|.|:||.:..|.||.|:|.|||:.|||||||.....|.|.
Zfish   328 AREFFEAFRQIPQRVLWRYTGPVPENAPKNVKLMKWLPQNDLLGHPKVRAFVTHGGSHGIYEGIC 392

  Fly   371 HAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGISFRYR 435
            :..|::.||:|.||..|.......|....|....:.:.:...|::::.::.||.:.:..:|..:|
Zfish   393 NGVPMVMLPLFGDQGDNAQRLVSRGVAESLTIYDVTSEKLLVALKKVINDKSYKEKMMKLSAIHR 457

  Fly   436 DQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFVVMVLLLIVLPITIYKL 500
            |:...|::.|::|.|.|.||:||.:|:.||..|||.|||::||  |.|::::||.::. :|:...
Zfish   458 DRPIEPLDLAVFWTEFVMRHKGAEHLRPAAHDLNWIQYHSLDV--IGFLLLILLTVIF-VTVKSC 519

  Fly   501 L---KKLLLKGER 510
            :   :|...|.::
Zfish   520 MFCFRKCFKKSQK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	139/498 (28%)
ugt1ab	NP_998587.2	UDPGT	37..524	CDD:278624	137/502 (27%)
ugt1ab	NP_998587.2	egt	<279..513	CDD:223071	88/238 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.760