DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and Ugt1a3

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_958827.1	Gene:	Ugt1a3 / 396551	RGDID:	1549728	Length:	531	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	153/568 - (26%)
Similarity:	258/568 - (45%)	Gaps:	108/568 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFP------------- 58
            :|.|||:|.::.| ..::|....| ||:.....:.:.|...||...|::  |
  Rat    13 LLLLLCALPWAEG-GKVLVFPMEG-SHWLSMRDVVRELHARGHQAVVLA--PEVTVHIKEEDFFT 73

  Fly    59 -QKKPIPGYTDVSVPNVIEVMGGDIGALWASIQKTYTQNLIDHYQMGF----------------- 105
             |..|:| ||                      ::.|..:|:.|.|..|
  Rat    74 LQTYPVP-YT----------------------KEEYRHHLLGHLQNFFETEFSLKLVLQRMAAVN 115

  Fly   106 -------RITRGLFEDSNFQDFLKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFI 163
                   |..|||..::.....|.|: |||.::.:.|: .....||.:...|.:        .|:
  Rat   116 NVSTFYVRSCRGLLHNTALIQSLNSS-SFDVVLTDPFF-PCGAVLAMYLRVPAV--------FFL 170

  Fly   164 TDMV--------GSPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKE 220
            ..|:        .||.|:|::|.::...:||||..:|:.|:           .|.:|.....:..
  Rat   171 QSMLCELEFEATNSPNPSSYIPRLLTLNSDHMSFLDRVKNM-----------LYPVPWMYLCHVN 224

  Fly   221 FFPGNKRCFYKMRRNASLVLINQHVSL---------SFPRPHSPNMIEVGGMHIDGKWNPLPEKI 276
            :....:.....::|..|:|.|.:|.|:         .:|||..|||:.:||::...: .||.::.
  Rat   225 YGSLARLASDLLQREVSVVEILRHASVWLLRKDFVFYYPRPFMPNMVFIGGINCANR-KPLSQEF 288

  Fly   277 ERFINES-EHGAIYFSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISD 340
            |.::|.| |||.:.||:||  ...::|..|..||.:|||.:.|.|||::......|..:|..:..
  Rat   289 EAYVNASGEHGIVVFSLGS--MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVK 351

  Fly   341 WFPQTDILAHPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTL 405
            |.||.|:|.|||..||:||.|.....|.|.:..|::.:|:|.||..|....|..|.|:.|:...:
  Rat   352 WLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEM 416

  Fly   406 NAVEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNW 470
            .|.:...|::.:.:..||.:.:..:|..::|:...|::.|::|||:|.||:||.:|:.||..|.|
  Rat   417 TADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTW 481

  Fly   471 WQYHNVDVL-LIIFVVMVLLLIVLPITIYKLLKKLLLKGERTQSTKVK 517
            :|||::||: .::.:|:.::.||.....|...|....||...:|.|.|
  Rat   482 YQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	143/529 (27%)
Ugt1a3	NP_958827.1	UDPGT	26..522	CDD:278624	144/545 (26%)
Ugt1a3	NP_958827.1	egt	<228..505	CDD:223071	92/279 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860