DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_964007.2	Gene:	Ugt1a1 / 394436	MGIID:	98898	Length:	535	Species:	Mus musculus

Alignment Length:	539	Identity:	148/539 - (27%)
Similarity:	253/539 - (46%)	Gaps:	54/539 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQ--------------K 60
            |||..|.|:.:...:::.....||:.....:.:.|.:.||.:.|::  |:              |
Mouse    18 LLCVFGPSASHAGRLLVFPMDGSHWLSMLGVIQQLQQKGHEVVVIA--PEASIHIKEGSFYTLRK 80

  Fly    61 KPIPGYTDVSVPNVIEVMGGDIGALWASIQKTYTQNLIDHYQMGFRITRG----------LFEDS 115
            .|:|...:.....::|:      ...|..|.::...::..|   .::.|.          |..::
Mouse    81 FPVPFQKENVTATLVEL------GRTAFNQDSFLLRVVKIY---MKVKRDSSMLLAGCSHLLHNA 136

  Fly   116 NFQDFLKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGSPAPASFVPHIM 180
            .|...|:.:. |||::.:.|...... :|::...|.:........:..::....|.|.|:||. .
Mouse   137 EFMASLEESH-FDALLTDPFLPCGSI-VAQYLTVPTVYFLNKLPCSLDSEATQCPVPLSYVPK-S 198

  Fly   181 LPFN-DHMSLYERLLNVAFLGYE----RVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRRNASLVL 240
            |.|| |.|:..:|:.||.....|    ||:...|.....|.|.||.      ....:...||:.|
Mouse   199 LSFNSDRMNFLQRVKNVLLAVSENFMCRVVYSPYGSLATEILQKEV------TVQDLLSPASIWL 257

  Fly   241 INQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKDLPPS 304
            :.......:|||..|||:.:||::...| .||.::.|.::|.| |||.:.||:||  ...::|..
Mouse   258 MRSDFVKDYPRPIMPNMVFIGGINCLQK-KPLSQEFEAYVNASGEHGIVVFSLGS--MVSEIPEK 319

  Fly   305 KVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESI 369
            |..||.:|||.:.|.|||::......|..:|..:..|.||.|:|.|||..||:||.|.....|.|
Mouse   320 KAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGI 384

  Fly   370 YHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGISFRY 434
            .:..|::.:|:|.||..|....|..|.|:.|:...:.|.:...|::.:.:..||.:.:..:|..:
Mouse   385 CNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLH 449

  Fly   435 RDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-LIIFVVMVLLLIVLPITIY 498
            :|:...|::.|::|||:|.||:||.:|:.||..|.|:|||::||: .::.:|:.::.||.....|
Mouse   450 KDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAY 514

  Fly   499 KLLKKLLLKGERTQSTKVK 517
            ...|....||...:|.|.|
Mouse   515 GCRKCFGGKGRVKKSHKSK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	138/500 (28%)
Ugt1a1	NP_964007.2	egt	20..507	CDD:223071	137/509 (27%)
Ugt1a1	NP_964007.2	UDPGT	30..526	CDD:278624	140/518 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840316
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690