DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and Ugt1a6b

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_958812.3	Gene:	Ugt1a6b / 394435	MGIID:	3580629	Length:	531	Species:	Mus musculus

Alignment Length:	543	Identity:	162/543 - (29%)
Similarity:	258/543 - (47%)	Gaps:	90/543 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYTD------VSVPNVIE----- 76
            |:|:...| ||:.....:.:.|.:.||.|.|  :.|:...:.|.:.      .|||..:|
Mouse    29 LLVVPQDG-SHWLSMKEIVEHLSERGHDIVV--LVPEVNLLLGESKYYRRKIFSVPYSLEELQTR 90

  Fly    77 ---------VMGGDI-GALWASIQKTYTQNLIDHYQMGFRITRGLFEDSNFQDFLKSNQSFDAII 131
                     |.|..: |.|     :.|..:::. .:|.|...:.|.:||....||:.|: |||:.
Mouse    91 FRTFGRNQFVPGAPLMGPL-----REYRNSMLT-LEMFFSNCQSLLKDSATLSFLRENK-FDALF 148

  Fly   132 ------CETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVG-SPAPASFVPHIMLPFNDHMSL 189
                  |...       |||:.|.|.:.|..|...: :..|:| ||:|.|:||.....|:|||:.
Mouse   149 TDPAMPCGVI-------LAEYLNLPSVYLFRGFPCS-LEHMLGQSPSPVSYVPRFYTKFSDHMTF 205

  Fly   190 YERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYK---------MRRNASLVLINQHV 245
            .:||.|......|..|  ||                  |.|.         ::|:.||..::|:
Mouse   206 PQRLANFIVNILENYL--YY------------------CLYSKYEIIVTDLLKRDVSLPSLHQN- 249

  Fly   246 SL---------SFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKD 300
            ||         .:|||..||||.:||::...| ..|.::.|.::|.| |||.:.||:||  ...:
Mouse   250 SLWLLRYDFVFEYPRPIMPNMIFIGGINCKKK-GKLTQEFEAYVNASGEHGIVVFSLGS--MVSE 311

  Fly   301 LPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLST 365
            :|..|..||.:|||.:.|.|||::......|..:|..:..|.||.|:|.|||..||:||.|....
Mouse   312 IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGI 376

  Fly   366 TESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGI 430
            .|.|.:..|::.:|:|.||..|....|..|.|:.|:...:.|.:...|::.:.:..||.:.:..:
Mouse   377 YEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRL 441

  Fly   431 SFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-LIIFVVMVLLLIVLP 494
            |..::|:...|::.|::|||:|.||:||.:|:.||..|.|:|||::||: .::.:|:.::.||..
Mouse   442 SSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFK 506

  Fly   495 ITIYKLLKKLLLKGERTQSTKVK 517
            ...|...|....||...:|.|.|
Mouse   507 CCAYGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	152/504 (30%)
Ugt1a6b	NP_958812.3	egt	15..503	CDD:223071	153/515 (30%)
Ugt1a6b	NP_958812.3	UDPGT	27..522	CDD:278624	159/534 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840702
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690