DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and Ugt1a9

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_964006.2	Gene:	Ugt1a9 / 394434	MGIID:	3576092	Length:	528	Species:	Mus musculus

Alignment Length:	550	Identity:	159/550 - (28%)
Similarity:	256/550 - (46%)	Gaps:	78/550 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LCSLGYSSGYNYLMVLNSAGR--------SHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYT 67
            ||.| .:||      |..|||        ||:.....:.:.|:..||.:.||        ||..:
Mouse    12 LCLL-LASG------LAQAGRLLVVPMDGSHWFTMQMVVEKLIHRGHEVVVV--------IPEVS 61

  Fly    68 ------------DVSVPNVIEVMGGDIGAL----WA----SIQKTYTQNLIDHYQMGFRITRGLF 112
                        ..|:.:.:|.:..:...|    |.    ||:...|.:....:::.|...|.||
Mouse    62 WQLGKSLNCTVKTYSISHTLEDLDREFKYLSYTQWKTPEHSIRSFLTGSARGFFELTFSHCRSLF 126

  Fly   113 EDSNFQDFLKSNQSFDAIICETFYNDAHYGL--AEHFNAPLIGLATGGGLTFITDMVGSPAPASF 175
            .|....::|| .:.|||:..:.|  |. .||  |::|:.|.:..|.|....::.:....|:..|:
Mouse   127 NDKKLVEYLK-QRFFDAVFLDPF--DV-CGLIVAKYFSLPSVIFARGVFCDYLEEGAQCPSLPSY 187

  Fly   176 VPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKE-----------FFPGNKRCF 229
            ||.:...:.|.|:..||:.|......|..... |||.|..::..|           |.|
Mouse   188 VPRLFSKYTDTMTFKERVWNHLIYIEEHAFCS-YFLRTAVEVASEILQTPVTMTDLFSP------ 245

  Fly   230 YKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMG 293
                  .|:.|:.....|.||||..|||:.:||::...| ..|.::.|.::|.| |||.:.||:|
Mouse   246 ------VSIWLLRTDFVLEFPRPVMPNMVFIGGINCLQK-KSLSKEFEAYVNASGEHGIVVFSLG 303

  Fly   294 SNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVT 358
            |  ...::|..|..||.:|||.:.|.|||::......|..:|..:..|.||.|:|.|||..||:|
Mouse   304 S--MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFIT 366

  Fly   359 HGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSY 423
            |.|.....|.|.:..|::.:|:|.||..|....|..|.|:.|:...:.|.:...|::.:.:..||
Mouse   367 HSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSY 431

  Fly   424 TKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-LIIFVVMV 487
            .:.:..:|..::|:...|::.|::|||:|.||:||.:|:.||..|.|:|||::||: .::.:|:.
Mouse   432 KENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLT 496

  Fly   488 LLLIVLPITIYKLLKKLLLKGERTQSTKVK 517
            ::.||.....|...|....||...:|.|.|
Mouse   497 VVFIVFKCCAYGCRKCFGGKGRVKKSHKSK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	149/511 (29%)
Ugt1a9	NP_964006.2	egt	9..500	CDD:223071	150/522 (29%)
Ugt1a9	NP_964006.2	UDPGT	24..519	CDD:278624	149/522 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840364
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690