DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_964005.2	Gene:	Ugt1a5 / 394433	MGIID:	3032634	Length:	529	Species:	Mus musculus

Alignment Length:	554	Identity:	147/554 - (26%)
Similarity:	255/554 - (46%)	Gaps:	87/554 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITV----VSVFPQKKPIPGYTDVS 70
            |||:|.::.|...|:.  ..|.||:.....:.:.|...||...|    |::..:::....:...:
Mouse    15 LLCALPWTEGEKVLVF--PVGGSHWLSMRDVVRELHAQGHQTVVLAPEVNMRIKEEDFFTFKVYA 77

  Fly    71 VPNVIEVMGGDIGALWASIQKTYTQNLIDHYQMGFRITRGLFEDSNF-QDFLKSNQ---SFDAII 131
            ||                    ||:..::......::   .|:..|: :...|:::   :...::
Mouse    78 VP--------------------YTRQELEEMMENLKV---FFDTGNYMKKIFKTSEALRNMSTVL 119

  Fly   132 CETFYNDAH-YGLAEHFN-------------------APLIGLATGGGLTFIT-----DMVGSPA 171
            .:|..|..| ..|..|.|                   |..:|:.....|.:|.     :....|:
Mouse   120 LKTCTNILHNESLLHHLNSSSFDVVFTDPVFPCGALLAKYLGIPAVFFLRYIPCGIEYEATQCPS 184

  Fly   172 PASFVPHIMLPFNDHMSLYERLLNVAFLGYERVL--LDYYFLPTQEKLYKEFFPGNKRCFYKMRR 234
            |:|::|::....:|||...:|:.|:.   |..||  :.:..:...|.|..|.|          :|
Mouse   185 PSSYIPNLFTRLSDHMDFLQRVQNML---YHLVLKYICHLLITPYESLASELF----------QR 236

  Fly   235 NASLVLINQHVS---------LSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIY 289
            ..|.|.:..:.|         |.:|||..|||:.:||::...| .||.::.|.::|.| |||.:.
Mouse   237 EVSSVELFSYASVWLFRGDFVLDYPRPIMPNMVFIGGINCVTK-KPLSQEFEAYVNASGEHGIVV 300

  Fly   290 FSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIM 354
            ||:||  ...::|..|..||.:|||.:.|.|||::......|..:|..:..|.||.|:|.|||..
Mouse   301 FSLGS--MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTR 363

  Fly   355 AFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITS 419
            ||:||.|.....|.|.:..|::.:|:|.||..|....|..|.|:.|:...:.|.:...|::.:.:
Mouse   364 AFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVIN 428

  Fly   420 EPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-LIIF 483
            ..||.:.:..:|..::|:...|::.|::|||:|.||:||.:|:.||..|.|:|||::||: .::.
Mouse   429 NKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLA 493

  Fly   484 VVMVLLLIVLPITIYKLLKKLLLKGERTQSTKVK 517
            :|:.::.||.....|...|....||...:|.|.|
Mouse   494 IVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	137/515 (27%)
Ugt1a5	NP_964005.2	UDPGT	26..520	CDD:278624	139/534 (26%)
Ugt1a5	NP_964005.2	egt	<257..501	CDD:223071	87/246 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840641
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690