DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_964004.1	Gene:	Ugt1a7c / 394432	MGIID:	3032636	Length:	531	Species:	Mus musculus

Alignment Length:	554	Identity:	165/554 - (29%)
Similarity:	266/554 - (48%)	Gaps:	70/554 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FTLILGLLCSLGYSSGYNYLMVLNSAGR--------SHFNVGHALAKGLVKAGHTITVVSVFPQ- 59
            |...|.|...|..:||      |..|||        ||:.....:.:.|:..||.:.|  |.|:
Mouse     6 FPASLPLCVCLLLASG------LAQAGRLLVVPMDGSHWFTMQTVVEKLLHKGHEVVV--VVPEV 62

  Fly    60 ----KKPI--------PGYTDVSVPNVIEVMGGDIGALWASIQKTYTQNLID-----HYQMGFRI 107
                .||:        ..:|...:....::.   |.|.|.|.|:.....|:|     .:::.|..
Mouse    63 SWQLTKPLNFVVKTYAVSHTQEDLNREFKIF---IDAQWKSQQEGGILPLLDSPAKGFFELLFSH 124

  Fly   108 TRGLFEDSNFQDFLKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGSPAP 172
            .|.||.|....::||.. ||||:..:.| :.....:|::|:.|.:..:.|....::.|....|:|
Mouse   125 CRSLFNDKKLVEYLKQT-SFDAVFLDPF-DVCGLTVAKYFSLPSVVFSRGIFCHYLEDAAQCPSP 187

  Fly   173 ASFVPHIMLPFNDHMSLYERLLN-VAFLGYERVLLDYYF----------LPTQEKLYKEFFPGNK 226
            .|::|.::|.|.|.|:..||..| :|::| ||.....:|          |.|...:...|.|
Mouse   188 PSYIPRMLLKFTDTMTFKERTRNLLAYMG-ERAFCHKFFKSAADIASEVLQTPVTMTDLFSP--- 248

  Fly   227 RCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHI-DGKWNPLPEKIERFINES-EHGAIY 289
                     .|:.|:.....|.||||..||:|.:||::. .||  ||.::.|.::|.| |||.:.
Mouse   249 ---------VSIWLLRTDFVLEFPRPVMPNVIYIGGINCHQGK--PLSKEFEAYVNASGEHGIVV 302

  Fly   290 FSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIM 354
            ||:||  ...::|..|..||.:|||.:.|.|||::......|..:|..:..|.||.|:|.|||..
Mouse   303 FSLGS--MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTR 365

  Fly   355 AFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITS 419
            ||:||.|.....|.|.:..|::.:|:|.||..|....|..|.|:.|:...:.|.:...|::.:.:
Mouse   366 AFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVIN 430

  Fly   420 EPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-LIIF 483
            ..||.:.:..:|..::|:...|::.|::|||:|.||:||.:|:.||..|.|:|||::||: .::.
Mouse   431 NKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLA 495

  Fly   484 VVMVLLLIVLPITIYKLLKKLLLKGERTQSTKVK 517
            :|:.::.||.....|...|....||...:|.|.|
Mouse   496 IVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	155/515 (30%)
Ugt1a7c	NP_964004.1	UDPGT	26..522	CDD:278624	154/519 (30%)
Ugt1a7c	NP_964004.1	egt	<225..503	CDD:223071	96/293 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840700
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136043
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.690