DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and Ugt1a10

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_964003.2	Gene:	Ugt1a10 / 394430	MGIID:	3580642	Length:	530	Species:	Mus musculus

Alignment Length:	557	Identity:	163/557 - (29%)
Similarity:	261/557 - (46%)	Gaps:	77/557 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FTLILGLLCSLGYSSGYNYLMVLNSAGR--------SHFNVGHALAKGLVKAGHTITVVSVFPQK 60
            |...|.|...|..:||      |..|||        ||:.....:.:.|::.||.:.||
Mouse     6 FPTSLPLCVCLLLASG------LVQAGRLLVVPMDGSHWFDMQMVVEKLIQRGHEVVVV------ 58

  Fly    61 KPIPGYT------------DVSVPNVIEVMGGDIG----ALW----ASIQKTYTQNLIDHYQMGF 105
              ||..:            ..||.:.:|.:..:..    ..|    .||:...|.:....:::.|
Mouse    59 --IPEVSWRLGKSLNCTVKTYSVSHTLEDLDREFKYFTYTQWKTPEQSIRSFMTGSARGFFELMF 121

  Fly   106 RITRGLFEDSNFQDFLKSNQSFDAIICETFYNDAHYGL--AEHFNAPLIGLATGGGLTFITDMVG 168
            ..:||||.|....::|| .:||||:..:.|  |. .||  |::.:.|.:..|......::.:...
Mouse   122 SHSRGLFNDKKLVEYLK-QRSFDAVFLDPF--DV-CGLIVAKYLSLPSVIFARLSFCYYLEEGAQ 182

  Fly   169 SPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYF----------LPTQEKLYKEFFP 223
            .|:..|:||.:...:.|.|:..||:.|......:.|...|:|          |.|...:...|.|
Mouse   183 CPSLLSYVPRLFSKYTDTMTFKERVWNHYMYIEDYVFCPYFFKTAVEIASEVLQTPVTMTDLFSP 247

  Fly   224 GNKRCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMH-IDGKWNPLPEKIERFINES-EHG 286
                        .|:.|:.....|.||||..|||:.||||: :.||  ||.::.|.::|.| |||
Mouse   248 ------------VSIWLLRTDFVLEFPRPVMPNMVFVGGMNCLQGK--PLSKEFEAYVNASGEHG 298

  Fly   287 AIYFSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHP 351
            .:.||:||  ...::|..|..||.:|||.:.|.|||::......|..:|..:..|.||.|:|.||
Mouse   299 IVVFSLGS--MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHP 361

  Fly   352 KIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIER 416
            |..||:||.|.....|.|.:..|::.:|:|.||..|....|..|.|:.|:...:.|.:...|::.
Mouse   362 KTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKT 426

  Fly   417 ITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-L 480
            :.:..||.:.:..:|..::|:...|::.|::|||:|.||:||.:|:.||..|.|:|||::||: .
Mouse   427 VINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGF 491

  Fly   481 IIFVVMVLLLIVLPITIYKLLKKLLLKGERTQSTKVK 517
            ::.:|:.::.||.....|...|....||...:|.|.|
Mouse   492 LLAIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	153/518 (30%)
Ugt1a10	NP_964003.2	egt	14..502	CDD:223071	151/521 (29%)
Ugt1a10	NP_964003.2	UDPGT	26..521	CDD:278624	152/522 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840365
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.730