DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and ugt-35

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001023694.1	Gene:	ugt-35 / 3565443	WormBaseID:	WBGene00044286	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	557	Identity:	136/557 - (24%)
Similarity:	243/557 - (43%)	Gaps:	75/557 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILGLLCSLGY--SSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTIT-----VVSVFPQKKPIP 64
            ||..|.|:.:  |...|:|:.......||......:|..|.:.||.:|     :|..:...|.:.
Worm     7 ILFFLISILFQNSKSVNFLVYCPLFAHSHHTFLAKIADTLSEEGHNVTFLAPIIVQKYENFKYLK 71

  Fly    65 GYTDV-------SVPNVIEVMGGDIGALWASIQKTYTQN--------LIDHYQMGF-RITRGLFE 113
            ..||:       .:..:.|:||.      |...|.:|:.        .|..:|..| :|...|..
Worm    72 HTTDIIYIQPDEELKKLGEIMGS------AGFSKYWTEEPSVFSMIPSIKLFQKMFHKIYENLRA 130

  Fly   114 DSNFQDFLKSNQSFDAIICETFYNDA-----HYGLAEHFNAPLIGLATGGGLTFITDMVGSPAPA 173
            |.:..|.|| ::.|||:|.|....:|     :.|:...:  |...:..|   ..::..:|.||..
Worm   131 DLSILDSLK-DRKFDAMIYEVLAFNAIAIQQYLGIKTLY--PTFSVTHG---MVLSKSIGEPASP 189

  Fly   174 SFVPHIMLPFNDHMSLYERLLNV--AFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRRNA 236
            :.:...:.|:.:.|:..|||:|.  ||:        |.......|:.....|..:....:....|
Worm   190 ATLSSALSPYGEKMNFQERLMNTVCAFI--------YQVFMKPPKMISYSHPYYEIDLKEAESKA 246

  Fly   237 SLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINESEH------GAIYFSMGSN 295
            |.|.:|.:..|.||||.....:.:||:.:    |....:.||..:|..:      ..:..|.||.
Worm   247 SFVFLNSNPYLDFPRPMLTKTVLIGGISV----NTSQIREERLSDEYHNILNIRVKTVLISFGSI 307

  Fly   296 LKTKDLPPSKVQEILKALGGLKQ-RVLWKFELDNL--PNKPENVYISDWFPQTDILAHPKIMAFV 357
            :.:.|:|......|:|.:..... ..:||:|.|.|  .|..:|::...|.|||.:||..::.||:
Worm   308 MLSTDMPDRYKSIIVKVIEEFPNVTFIWKYESDELDFANNLKNLHFFKWIPQTALLADSRLSAFI 372

  Fly   358 THGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTL-NAVEFRKAIERITSEP 421
            ||.|:.|..|..|..||.|.:|||:||..|.....::...|.|:.:.| |..:.|.::.:|..:.
Worm   373 THAGLGSINELSYMGKPAILVPIFADQLRNAKMLVRHNGSISLEKQDLGNFEKLRVSLAKILKDN 437

  Fly   422 SYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAY-----LKSAAQRLNWWQYHNVDVLLI 481
            |:.:..:.::.:..:|..:|.|   ..::|.|  .||.:     |...:::::::..:.:|:.|.
Worm   438 SFQENAEILARQLNNQPISPRE---LLIKHAT--FGAEFGELPSLDPYSRQMSFFSLNMIDIFLF 497

  Fly   482 IFVVMVLLLIVLPITIYKLLKKLLLKGERTQSTKVKR 518
            :.|.:.:|:..| .|..:||..||||.:..:.::..|
Worm   498 LGVFLAILVYFL-FTFLRLLLNLLLKKKAVEKSQENR 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	124/517 (24%)
ugt-35	NP_001023694.1	Glycosyltransferase_GTB_type	2..464	CDD:299143	118/483 (24%)
ugt-35	NP_001023694.1	UDPGT	34..506	CDD:278624	119/500 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810