DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and Ugt2b10

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001178605.1	Gene:	Ugt2b10 / 305264	RGDID:	1309989	Length:	532	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	170/554 - (30%)
Similarity:	260/554 - (46%)	Gaps:	91/554 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RTFTLILGLLCSLG--YSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVV---------- 54
            ||.:|:| ||..|.  :.||....:::.....||:.....:...|:|.||.:||:
  Rat     5 RTASLLL-LLLQLSDFFGSGTGGKVLVWPMEFSHWLNLRVILDELLKKGHEVTVLRPSASLSYEV 68

  Fly    55 --------SVFPQKKPIPGYTDVSVPNVIEVMGGDIGALWASIQKTYTQNLIDHYQMGFRITRGL 111
                    ..:|        |..|:..|.|.       .|.|::| |...|......|:.:   :
  Rat    69 DNTSAIEFETYP--------TSYSLTEVDEF-------FWESLRK-YIYELPKQSFWGYFL---M 114

  Fly   112 FE-----DSN-FQDFLK------------SNQSFDAIICETFY--NDAHYGLAEHFNAPLI-GLA 155
            |:     ||: |:...|            .|..||.|:.:.|.  .|.   |||....||: .|.
  Rat   115 FQELVWVDSDYFESLCKDVVFNKELMTKLQNSGFDVILADPFIPCGDL---LAEILKIPLVYSLR 176

  Fly   156 TGGGLTFITDMVGSPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKE 220
            ...|.|:.....|.|.|.|:||..|...:|.|:..||:.::.::    :..|::|....||.:.|
  Rat   177 FFPGSTYEKYSGGLPMPPSYVPIAMSELSDRMTFVERMKHMIYV----LCFDFWFQAFNEKKWNE 237

  Fly   221 FFP---GNKRCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINE 282
            .:.   |......:....|.:.||..:..|.||.|..||...|||:|.... .|||::||.|:..
  Rat   238 LYTEVLGRPTTLSETMAKADIWLIRTYWDLEFPHPVLPNFDFVGGLHCRPA-KPLPKEIEDFVQS 301

  Fly   283 S-EHGAIYFSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPE----NVYISDWF 342
            | |||.:.||:||  ...:|...:...|...|..:.|:|||:||    ..|||    |..:..|.
  Rat   302 SGEHGVVVFSLGS--MVGNLTEERANVIAAGLAQIPQKVLWRFE----GKKPETLGSNTRLYKWI 360

  Fly   343 PQTDILAHPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNA 407
            ||.|:|.|||..||:||||.....|:|||..||:|:|:|.||:.|:.|.:..|..:.|||.|:::
  Rat   361 PQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQYDNIVHLKTKGAAVRLDFLTMSS 425

  Fly   408 VEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQ 472
            .:...|::.||::|||.:....:|..:.||...|::.|::|:|.|.||:||.:|:.||..|:|.|
  Rat   426 TDLFTALKTITNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWVQ 490

  Fly   473 YHNVDVLLIIFVVMVLLLIVLPITIYKLLKKLLL 506
            ||::||        :..|:...:|:..:|||..|
  Rat   491 YHSLDV--------IGFLLACVVTVMFILKKCCL 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	164/526 (31%)
Ugt2b10	NP_001178605.1	UDPGT	26..529	CDD:278624	161/532 (30%)
Ugt2b10	NP_001178605.1	egt	35..510	CDD:223071	157/515 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344112
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830