DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001129341.1	Gene:	Ugt2a3 / 289533	RGDID:	1308444	Length:	534	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	154/529 - (29%)
Similarity:	249/529 - (47%)	Gaps:	69/529 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SHFNVGHALAKGLVKAGHTITVVS----VFPQKK---------PIPGYTDVSVPNVIEVMGGDIG 83
            ||:.....:.:.|...||.:||:.    :..|.|         |:...|:|:..::.|::...:.
  Rat    34 SHWLNLKTILEELAARGHEVTVLKYPSIIIDQSKLTPLQFENIPVLYETEVAENHLNEIVNLAVN 98

  Fly    84 -----ALWASIQKTYTQNLIDHYQMGFRITRGLFEDSNFQDFLKSNQSFDAIICETFYN------ 137
                 :||.:     .:.|.|.:   .::|      .||:|..:|          |.||
  Rat    99 VIPNLSLWEA-----ARTLQDFF---LQLT------GNFEDLCRS----------TLYNQTLMNK 139

  Fly   138 --DAHYG-------------LAEHFNAPLIG-LATGGGLTFITDMVGSPAPASFVPHIMLPFNDH 186
              ||.|.             :||....|.:. |....|.:........|.|.|:||.:|....||
  Rat   140 LRDAKYDVMVLDPVIPCGELVAEVLQIPFVNTLRFSMGYSMEKYCGQLPVPLSYVPVVMGELTDH 204

  Fly   187 MSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRRNASLVLINQHVSLSFPR 251
            |:..||:.|:....:....|..|.....::.|.:.. |....|.|....|.:.||..:..:.|||
  Rat   205 MTFTERVKNMMLSLFFEFWLQQYDFAFWDQFYSKTL-GRPTTFCKTVGKAEIWLIRTYWDIEFPR 268

  Fly   252 PHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKDLPPSKVQEILKALGG 315
            |:.||...|||:|.... .|||:::|.|:..| |||.:.||:||.:  |:|...|...|..||..
  Rat   269 PYLPNFEFVGGLHCKPA-KPLPKELEEFVQSSGEHGVVVFSLGSMI--KNLTEEKANLIASALAQ 330

  Fly   316 LKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESIYHAKPVIGLPI 380
            :.|:|||::..........|..|.:|.||.|:|.|||..||:||||.....|:|||..|::|:|:
  Rat   331 IPQKVLWRYSGKKPATLGPNTRILNWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGVPMVGIPM 395

  Fly   381 FSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIENA 445
            |.||.:|:||.|..|..:.:...|:.:.:...|:..:.:||||.:....:|..:.||...|::.|
  Rat   396 FGDQPYNIAHMEAKGAAVKVAINTMTSADLLSALRAVINEPSYKENAMRLSRVHHDQPVKPLDRA 460

  Fly   446 IYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFVVMVLLLIVLPITIYKLLKKLLLKGER 510
            ::|:|.|.||:||.:|:.||..|:|:|||::||:..:.|.:|.|..|:......:.:|..|:..:
  Rat   461 VFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLVCVVTLTFVITKCSLFMCRKCCLRERK 525

  Fly   511 TQSTKVKRN 519
            .:..:.|:|
  Rat   526 KKGNRKKKN 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	146/488 (30%)
Ugt2a3	NP_001129341.1	UDPGT	25..519	CDD:278624	150/512 (29%)
Ugt2a3	NP_001129341.1	egt	<268..506	CDD:223071	93/240 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344022
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.790