DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and Ugt2b7

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_775445.2	Gene:	Ugt2b7 / 286989	RGDID:	708417	Length:	529	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	162/548 - (29%)
Similarity:	252/548 - (45%)	Gaps:	104/548 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVV----SVF--PQKK------- 61
            |:..|.||...|..::|:.               ||:.||.:||:    |||  |:|.
  Rat    27 LVWPLEYSHWMNLKIILDE---------------LVQRGHEVTVLRPSSSVFLDPKKASGLVYET 76

  Fly    62 -----------------------PIPGYTDVSVPNVIEVMGGDIGALWASIQKTYTQNLIDHYQM 103
                                   .:|.||.:.....:..|.|....||
  Rat    77 FPTTSNNDEVEKFFTQWVNTWTYDVPKYTCLRYYPSLNKMFGQFSDLW----------------- 124

  Fly   104 GFRITRGLFEDSNFQDFLKSNQSFDAIICETFYNDAHYG-----LAEHFNAPLI-GLATGGGLTF 162
             .::.|.:..:.:....||.:| ||.::     :|| .|     :||....|.: .|..|.|...
  Rat   125 -LQLCREVVSNKHLMAKLKESQ-FDVVL-----SDA-VGPCGELIAEILQLPFVYSLRFGIGYGI 181

  Fly   163 ITDMVGSPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFP---G 224
            .....|.|.|.|:||.|:...:..|:..||:.|:..|.|    .|::|.....|.:..||.   |
  Rat   182 EKYSAGQPFPPSYVPIILSGLSGQMTFMERVENMLCLLY----FDFWFESFPAKDWDPFFSEILG 242

  Fly   225 NKRCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAI 288
            .........:.|.:.||..:..|.||||..||:..|||:|.... .|||:::|.|...| |||.:
  Rat   243 RPTTMVDTMKKAEIWLIRSYWDLEFPRPSLPNIEFVGGLHCQPA-KPLPKEMEDFAQSSGEHGVV 306

  Fly   289 YFSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPE----NVYISDWFPQTDILA 349
            .||:||.:  :::...:...|..||..:.|:|.|:||    ..||:    |..:..|.||.|:|.
  Rat   307 VFSLGSMI--RNITQERANTIASALAQIPQKVFWRFE----GKKPDTLGPNTRVFKWIPQNDLLG 365

  Fly   350 HPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAI 414
            |||..|||||||.....|||:|..|::|:|:|::|..|:||....|..:.|||.|:::.:...|:
  Rat   366 HPKTKAFVTHGGANGIYESIHHGIPMVGIPLFAEQRDNVAHMVAKGAAVSLDFHTMSSSDLLNAL 430

  Fly   415 ERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDV- 478
            :.:.::|||.|.|..:|..:.||...|::.|::|:|.|.||:||.:|:..|..|.|:|||::||
  Rat   431 KAVINKPSYKKKVMWLSAIHHDQPLKPLDRAVFWIEFVMRHKGAKHLRPLAHNLAWYQYHSLDVI 495

  Fly   479 --LLIIFVVMVLLLIVLPITIYKLLKKL 504
              ||...:.:|||.:...:.:|:...|:
  Rat   496 GFLLACVLAIVLLAVKCCLFLYRFFVKV 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	155/522 (30%)
Ugt2b7	NP_775445.2	UDPGT	24..527	CDD:278624	162/548 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860