DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_036815.1	Gene:	Ugt1a1 / 24861	RGDID:	3935	Length:	535	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	150/530 - (28%)
Similarity:	252/530 - (47%)	Gaps:	36/530 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLCSLGYSSGY-NYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVV-----------SVFPQKK- 61
            |||.||.|:.: ..|:|:...| ||:.....:.:.|.:.||.:.|:           |.:..:|
  Rat    18 LLCVLGPSASHAGKLLVIPIDG-SHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKEGSFYTMRKY 81

  Fly    62 PIPGYTDVSVPNVIEVMGG---DIGALWASIQKTYTQNLIDHYQMGFRITRGLFEDSNFQDFLKS 123
            |:| :.:.:|......:|.   |.......:.|||.:...|. .|.......|..::.|...|:.
  Rat    82 PVP-FQNENVTAAFVELGRSVFDQDPFLLRVVKTYNKVKRDS-SMLLSGCSHLLHNAEFMASLEQ 144

  Fly   124 NQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGSPAPASFVPHIMLPFNDHMS 188
            :. |||::.:.|...... :|::.:.|.:........:...:....|||.|:||..:....|.|:
  Rat   145 SH-FDALLTDPFLPCGSI-VAQYLSLPAVYFLNALPCSLDLEATQCPAPLSYVPKSLSSNTDRMN 207

  Fly   189 LYERLLNVAFLGYERVLLDYYFLP----TQEKLYKEFFPGNKRCFYKMRRNASLVLINQHVSLSF 249
            ..:|:.|:.....|..|....:.|    ..|.|.||.      ....:...||:.|:.......:
  Rat   208 FLQRVKNMIIALTENFLCRVVYSPYGSLATEILQKEV------TVKDLLSPASIWLMRNDFVKDY 266

  Fly   250 PRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKDLPPSKVQEILKAL 313
            |||..|||:.:||::...| ..|.::.|.::|.| |||.:.||:||  ...::|..|..||.:||
  Rat   267 PRPIMPNMVFIGGINCLQK-KALSQEFEAYVNASGEHGIVVFSLGS--MVSEIPEKKAMEIAEAL 328

  Fly   314 GGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESIYHAKPVIGL 378
            |.:.|.|||::......|..:|..:..|.||.|:|.|||..||:||.|.....|.|.:..|::.:
  Rat   329 GRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMM 393

  Fly   379 PIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIE 443
            |:|.||..|....|..|.|:.|:...:.|.:...|::.:.:..||.:.:..:|..::|:...|::
  Rat   394 PLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLD 458

  Fly   444 NAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-LIIFVVMVLLLIVLPITIYKLLKKLLLK 507
            .|::|||:|.||:||.:|:.||..|.|:|||::||: .::.:|:.::.||.....|...|....|
  Rat   459 LAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGK 523

  Fly   508 GERTQSTKVK 517
            |...:|.|.|
  Rat   524 GRVKKSHKSK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	140/491 (29%)
Ugt1a1	NP_036815.1	UDPGT	30..526	CDD:278624	141/509 (28%)
Ugt1a1	NP_036815.1	egt	<263..509	CDD:223071	86/248 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760