DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_766469.1	Gene:	Ugt2b35 / 243085	MGIID:	3576100	Length:	529	Species:	Mus musculus

Alignment Length:	533	Identity:	156/533 - (29%)
Similarity:	243/533 - (45%)	Gaps:	77/533 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVV----SVFPQKKPIPGYTDVS 70
            |:..|.:|...|..::|:.               ||:.||.:||:    |:|...|..||....:
Mouse    27 LVWPLEFSHWMNLKIILDE---------------LVQRGHEVTVLRPSASIFVDPKYSPGLKFET 76

  Fly    71 VPNVIEVMGGDIGALWASIQKTYTQNLIDHYQMGFRITR-------------GLFED-------- 114
            .|.          |......:|:...|:|.:.  |.:.|             |...|
Mouse    77 FPT----------AFSKDYLETFLTKLVDEWT--FEVPRDTCLSYSLLQTLFGKLSDYSLSLCKE 129

  Fly   115 --SNFQDFLKSNQS-FDAIICETFYNDAHYG--LAEHFNAP-LIGLATGGGLTFITDMVGSPAPA 173
              ||.|...|..:| ||.:|.:..   |..|  :|:....| |..|....|.....:..|...|.
Mouse   130 AVSNKQLMTKFQESKFDVLILDAM---ASCGELIAQLLQIPFLYSLRFSPGYQVEKNSGGFVLPP 191

  Fly   174 SFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFP---GNKRCFYKMRRN 235
            |:||.|:......|:..||:.|:..:.|    .|::|....||.:.:|:.   |......:....
Mouse   192 SYVPVILSGLGGQMTFTERVKNMICMLY----FDFWFQTFTEKEWDQFYSETLGRPTTLIETMGK 252

  Fly   236 ASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTK 299
            |.:..|..:..|.||.|..||:..|||:|.... .|||:::|.|:..| .||.:.||:||  ...
Mouse   253 AEMWFIRSYWDLEFPHPTLPNVEYVGGLHCKPA-KPLPKEMEDFVQSSGVHGVVVFSLGS--MVS 314

  Fly   300 DLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLS 364
            ::...:...|..||..:.|:|||:|:.....:...|..|..|.||.|:|.|||..|||||||...
Mouse   315 NMTEERANAISWALAQIPQKVLWRFDGKTPASLGPNTRIYKWLPQNDLLGHPKTKAFVTHGGANG 379

  Fly   365 TTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQG 429
            ..|:|:|..|:||:|:||:|..|:||....|..:.|:.:|::..:...|:|.:.:.|||.:.|..
Mouse   380 LYEAIHHGIPMIGIPLFSEQHDNIAHMVAKGTAVALNIRTMSRSDLLNALEEVINNPSYKENVMW 444

  Fly   430 ISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFVVMVLLLIVLP 494
            :|..:.||...|:...|:|:|.|.||:||.:|:..|..|.|:|||::||:..: :|.|:...|||
Mouse   445 LSTIHHDQPMKPLNRTIFWIEFVMRHKGAKHLRPLAHNLTWYQYHSLDVIGFL-LVCVVATAVLP 508

  Fly   495 IT----IYKLLKK 503
            :.    :|:...|
Mouse   509 VKCCLFVYQFFVK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	149/504 (30%)
Ugt2b35	NP_766469.1	egt	8..506	CDD:223071	151/516 (29%)
Ugt2b35	NP_766469.1	UDPGT	24..525	CDD:278624	156/533 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840486
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690