DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	539	Identity:	150/539 - (27%)
Similarity:	266/539 - (49%)	Gaps:	54/539 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRTFTLILGLLCS-LGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAG-HTITVVSVFPQKKPI 63
            |:::|....||.| :|.:.....::|......||..:...||..|.:.| ||:.::|......|.
Mouse     1 MKSYTPYFMLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVLLLSEGRDIAPS 65

  Fly    64 PGYTDVSVPNVIEVMGGDIGALWASIQKTYTQNL--------IDHYQMGFRITRGLFEDSNFQDF 120
            ..|:....|.:......| ..|.:.::..::..|        :|||      |:..       |.
Mouse    66 NHYSLQRYPGIFNSTTSD-AFLQSKMRNIFSGRLTAVELVDILDHY------TKNC-------DM 116

  Fly   121 LKSNQS---------FDAIICETFYNDAHYGLAEHFNAPLIGL---ATGGGLTFITDMVGSPAPA 173
            :..||:         ||.::.:.  ||    :.....|.|:|:   ....||.:..: ||:|||.
Mouse   117 MVGNQALIQGLKKEKFDLLLVDP--ND----MCGFVIAHLLGVKYAVFSTGLWYPAE-VGAPAPL 174

  Fly   174 SFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRRNASL 238
            ::||.......|.|:..||:.|.......|:.:.:..||..|::.:::.....:..|.:...:||
Mouse   175 AYVPEFNSLLTDRMNFLERMKNTGVYLISRIGVSFLVLPKYERIMQKYNLLPAKSMYDLVHGSSL 239

  Fly   239 VLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFIN-ESEHGAIYFSMGSNLK--TKD 300
            .::...|:|.||||..||::.|||: :....:||||.::|::: ..|||.:..|.|:.:|  ::|
Mouse   240 WMLCTDVALEFPRPTLPNVVYVGGI-LTKPASPLPEDLQRWVSGAQEHGFVLVSFGAGVKYLSED 303

  Fly   301 LPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLST 365
            :    ..::..|||.|.|:|:|:|......|...|..:.:|.||.|:|.|..|.||::|||:.|.
Mouse   304 I----ANKLAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSI 364

  Fly   366 TESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGI 430
            .|::||..||:|:|:|.|.:..|...:..|.||:|::.|:...|...|:.::.:.|||.:..|.:
Mouse   365 FETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKL 429

  Fly   431 SFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFVVMVLLLIVLPI 495
            |..::||...|:....||::::.||.||.:|:||..::::.||..:|:..::.:..|||..:|..
Mouse   430 SEIHKDQPGHPVNRTTYWIDYILRHDGARHLRSAVHQISFCQYFLLDIAFVLLLGAVLLYFILSY 494

  Fly   496 T---IYKLLKKLLLKGERT 511
            .   ||:.:|.|..|.|.:
Mouse   495 VTKFIYRKIKSLWSKNEHS 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	140/503 (28%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	140/506 (28%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840748
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.790