DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt-31

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001021756.1	Gene:	ugt-31 / 189771	WormBaseID:	WBGene00021464	Length:	521	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	136/560 - (24%)
Similarity:	226/560 - (40%)	Gaps:	122/560 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYTDVSVPNVIEVMGGD 81
            |...|.|:.....|.||......:|..|.:|||.:|.:              |||.:|..
Worm    14 SEPLNILVYSPVFGGSHSKFMGNIADTLTEAGHNVTFL--------------VSVADVTR----- 59

  Fly    82 IGALWASIQKTYTQNLIDHYQMGFRITRG--LFEDSNF-QDFLK-------------SNQSFDAI 130
                              .:::|.::|:.  :.:..|| ||.::             .|:..|..
Worm    60 ------------------RHEIGVKLTKNVIIVDKPNFSQDDVEIDMDEVLRPLWTIQNRPSDFA 106

  Fly   131 ICETFY-----------------------NDAHYGLAE--------HFNAPLIGL---ATGGGLT 161
            .|..|:                       .:.|..:||        :|:|  :|:   ......|
Worm   107 TCFEFFIQMMQTTCAEFTSNREIFKKLSKTEFHVAIAEPVSICGLGYFDA--LGIKKTILASSTT 169

  Fly   162 FITDMV---GSPAPASFVPHIMLPFNDHMSLYERLLNVA----FLGYERVLLDYYFLPTQEKL-- 217
            ....:|   |.|...|:||.....|::.|.:::|..|.|    ..|....:.|......::.|
Worm   170 HYEGVVRNSGEPVDMSYVPVHGAYFDEKMDIFQRYTNWASEHVLAGNLERMFDQEMSEYRKNLVQ 234

  Fly   218 ----YKEFFPGNKRCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDG---KWNPLPEK 275
                :::..|           :|||:..|.:..|.||||.....:.:||:.:|.   |...||||
Worm   235 STGHWRDLIP-----------SASLMFTNSNPYLDFPRPVLQKTVGIGGITVDMEQIKSEKLPEK 288

  Fly   276 IERFINESEHGAIYFSMGSNLKTKDLPPSKVQEILKALGGLKQ-RVLWKFELDNL--PNKPENVY 337
            |.:.:.:.|:..: .|.||.:|:..:|......||.|:..... ..:||:|.|:|  ....|||:
Worm   289 INKLLEKREYNML-ISFGSMVKSSTMPEKWRNSILSAIRNFPNVTFIWKYESDDLRWAENVENVH 352

  Fly   338 ISDWFPQTDILAHPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLD- 401
            ...|.|||.:|.:|::.||:||||:.||.|..:..||.|.:|||.||..|.....::|..::|.
Worm   353 FLKWIPQTALLNNPRVSAFLTHGGLGSTNELAFIGKPSIIVPIFGDQGRNAPMLARHGGALVLQK 417

  Fly   402 FKTLNAVEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQ 466
            |...||......|.:|..:.||.|..:.::........:|.|..:...|.|........:....:
Worm   418 FDLENAEVLIDFIGKIVFDKSYAKNAKTLANLLNASPFSPKELVVKNTEFVGNFGPLTQMDPYIR 482

  Fly   467 RLNWWQYHNVDVLLIIFVVMVLLLIVLPITIYKLLKKLLL 506
            :|||:|....|:.||:|:|.. .:||:||.:.:.:.:|:|
Worm   483 KLNWFQRTFADIYLILFLVYA-SIIVIPIYVIRKVFRLIL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	126/532 (24%)
ugt-31	NP_001021756.1	UDPGT	28..518	CDD:278624	130/541 (24%)
ugt-31	NP_001021756.1	Glycosyltransferase_GTB_type	<248..472	CDD:299143	71/224 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860