DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt-42

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_503278.2	Gene:	ugt-42 / 185168	WormBaseID:	WBGene00017959	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	546	Identity:	135/546 - (24%)
Similarity:	233/546 - (42%)	Gaps:	89/546 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYTDVSVPN------VIE 76
            ||:|||:|..:.|.||......||..|.:|||.:||:|:....|    :.::|...      |:|
Worm    17 SGFNYLVVSPAFGHSHSTFMGKLADALTEAGHNVTVLSIIVSSK----FRNISYTKLTKDIVVVE 77

  Fly    77 -----------VMGGDIGALW---ASIQKTYTQNLI-----DHYQMGFRITRGLFEDSNFQDFLK 122
                       :...|....|   .::.:|....|:     ||....|| ...|.:    .::||
Worm    78 TTNEQDQQAENMENNDFSRYWTQEGTLLETIPSYLMFTKMSDHGYETFR-NHALPQ----MEYLK 137

  Fly   123 SNQ-SFDAIICETFYNDAHYGLA--EHFNAPLIGLATGGGLTF---ITDMVGSPAPASFVPHIML 181
            |:: .:||:..|::   .|.|.|  |:...|:....|  .||.   :.:::|.|...|::.....
Worm   138 SHRPRYDAVFFESY---LHTGKAIQEYLEIPVFLPVT--SLTHDYRLAELIGEPVSPSYLSGYFT 197

  Fly   182 PFNDHMSLYERLLNVAFLGYERVLLDYYFL--------------PTQEKLYK-EFFPGNKRCFYK 231
            .|.:.|:..||::|.         |.||..              |:::.|.: |::
Worm   198 NFGNIMNFQERVINT---------LSYYLAQILISSPNWKTLQDPSKDLLVESEYY--------- 244

  Fly   232 MRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDG---KWNPLPEKIERFINESEHGAIYFSMG 293
               .|..|.||.:..:.||||.....||:||:.:|.   |...:.|.....:....|. :..|.|
Worm   245 ---RAPYVFINSNPYIDFPRPLLSKTIEIGGITVDADALKSEKVDETWNNILKRRPHN-VLISFG 305

  Fly   294 SNLKTKDLPPSKVQEILKALGGLKQ-RVLWKFELD--NLPNKPENVYISDWFPQTDILAHPKIMA 355
            :..|:..:|.|....::|.:...|. ..:||:|.:  :..|..||:....|.|||.:||..::.|
Worm   306 TMFKSIHMPDSYKNNMVKVMKSFKNVTFIWKYESEETSFANGAENIIFKKWTPQTALLADSRLSA 370

  Fly   356 FVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVE-FRKAIERITS 419
            |.||||:.|..|..|..||.:..|:|:||..|.....::...|.:....|.:.. .|.|:..|..
Worm   371 FFTHGGLGSVNELSYLGKPALLCPLFADQVRNSKMLSRHNGSIEISKFNLESYNTLRSALHSILF 435

  Fly   420 EPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFV 484
            :.||.:..:.::.:...|...|.|..:...|...|......|....:.:.:..||.:||::.:..
Worm   436 DESYAENAEKLAKKLEFQPAKPKELFVRHAEFAARFGEQPALDCNLRTMGFATYHLLDVVVCLTS 500

  Fly   485 VMVLLLIVLPITIYKLLKKLLLKGER 510
            .:||:::.|.:.|.|:::.|.:|.:|
Worm   501 FVVLVILSLVVIIRKIVQSLAIKMKR 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	127/514 (25%)
ugt-42	NP_503278.2	Glycosyltransferase_GTB_type	14..501	CDD:299143	127/519 (24%)
ugt-42	NP_503278.2	UDPGT	22..495	CDD:278624	122/508 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810