DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt-18

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_506209.2	Gene:	ugt-18 / 179759	WormBaseID:	WBGene00013900	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	144/571 - (25%)
Similarity:	252/571 - (44%)	Gaps:	97/571 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FTLILGLLCSLGYSSGYNYLMVLNSA-GRSHFNVGHALAKGLVKAGHTITVVSVFPQ----KKPI 63
            |.|||..:  |.:|:....::|.|.| |.||.|....::..|:.|||.:|:  :.|:    ||..
Worm     3 FALILFFV--LIHSTLTYKVLVFNPAYGASHSNFLGKISDILIDAGHNVTM--LIPEYLITKKDF 63

  Fly    64 PGYTDVSVPNVIEVMGGDIGA----------------LW-------ASIQKTYTQNLIDHYQMGF 105
            .|  ...|.:|:.: |.|..|                :|       :.:....:.||...||..:
Worm    64 VG--SKKVKDVVRI-GRDERAGKLFEEEGIEHMGRARVWRMDPEMMSLVTIVGSMNLAIGYQCEY 125

  Fly   106 RITRGLFEDSNFQDFLKSNQSFDAIICETFYNDA-----HYGLAEHFNAPLIGLATGGGLTFITD 165
                 :|:..:..|.|: |:.||..|.|:.:...     |.|:....||.         .....|
Worm   126 -----IFQQKDIIDRLR-NEHFDLAITESLFACPFALFDHIGIKNVINAE---------SNLFKD 175

  Fly   166 MV----GSPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEK---LYKEFFP 223
            .|    |.||..|:.|.:..|.:|.||...|:.|:..:.:.:    |.:....||   :.|.::.
Worm   176 AVKYAHGEPAAISYYPGLFSPHDDKMSFVARVKNMITMLFTK----YLYGSRYEKELEMIKPYYN 236

  Fly   224 GNKRCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHID---------GKWNPLPEKIERF 279
            |.: .:..:....:..|||.:..:.:|.|..|..:.||||.::         .:||       ..
Worm   237 GTE-TWEDLFTGVAFNLINSNQYIDYPSPALPKTVFVGGMQVNTNEAKTKLSDEWN-------NI 293

  Fly   280 INESEHGAIYFSMGSNLKTKDLPPSKVQEILKALGGLKQ-RVLWKFELDN--LPNKPENVYISDW 341
            :|..:.. :..|.|||..:.::|....:..|...|.:.: ..:||:|..|  |.:...||.::.|
Worm   294 LNIRKQN-VLISFGSNAFSSEMPEEFKKSFLYVFGNMPEITFIWKYEEANATLTSHLPNVKLTTW 357

  Fly   342 FPQTDILAHPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTL- 405
            .||.|:||..::..||||||:.||.|..|..||.:.:|:.:||..| ||..:...|.:...||:
Worm   358 MPQNDLLADDRLTLFVTHGGLGSTMELAYQGKPALIIPLMADQPRN-AHMLKRHGGCLQYHKTML 421

  Fly   406 -NAVEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLN 469
             ::.:..||.:.:.:|..|::..|.::...|||..:|.:..:...|....|.....|.|..:.||
Worm   422 GDSEQLLKAFKTVLTERKYSENAQRLARILRDQPVSPKDLVLKHCEFAVEHGALNSLNSRGRYLN 486

  Fly   470 WWQYHNVDVLLIIFVVMVLLLIVLPIT---IYKLLKKLLLKGERTQSTKVK 517
            .:|:::.|:...|.::.:|:|:.:..|   |:||:.::.|    :|.||::
Worm   487 TFQFYSFDIASSIVMLALLVLVFIYFTLLFIFKLVARIFL----SQKTKME 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	133/529 (25%)
ugt-18	NP_506209.2	UDPGT	19..512	CDD:278624	130/526 (25%)
ugt-18	NP_506209.2	Glycosyltransferase_GTB_type	<252..504	CDD:299143	72/260 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860