DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt-33

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_505692.2	Gene:	ugt-33 / 179464	WormBaseID:	WBGene00007946	Length:	522	Species:	Caenorhabditis elegans

Alignment Length:	557	Identity:	142/557 - (25%)
Similarity:	255/557 - (45%)	Gaps:	87/557 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TLILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYTDV 69
            ||.|..|..:|:...:|||:.......||......:|..|..|||.:|.::....:|    |.:|
Worm     4 TLFLCTLFLVGFVQPFNYLVFCPLYAHSHHKFLAKIADTLTDAGHNVTFLAPIVLRK----YENV 64

  Fly    70 ----SVPNVI--------EVMG--GDIGALW----ASIQ-----KTYTQNLIDHYQMGFRITRGL 111
                |..:::        |.:|  .:....|    .:||     :|:.:..:..|:       .|
Worm    65 KYLESTKDIVYIQPSKELEALGFTSNYSKFWTEDATAIQFVPAVRTFVKMFVQLYE-------DL 122

  Fly   112 FEDSNFQDFLKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDM---VGSPAPA 173
            .:|.:..|.|| |::||||:.| |.....:.:||:..  :..|.....:|..|.|   :|.|:..
Worm   123 KKDLSVLDELK-NRNFDAIVFE-FLCPTAFPIAEYLG--IKALLPSLSMTHHTQMSRWIGEPSSP 183

  Fly   174 SFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYF-----LPTQEKLYKEFFPGNKRCFYKMR 233
            :.:|.::..|.|.|:.:|||.|.  ||      |.:|     :|.......   |..|..||:|.
Worm   184 TVLPSMISSFGDDMNFWERLGNT--LG------DVFFTLFVDMPRMTSFSD---PERKIDFYEMS 237

  Fly   234 RNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDG---KWNPLPEKIERFINESEHGAIYFSMGSN 295
            ..|..:.:|.:..|.:.||.....:.:||:.::.   |...|.||.::.|:|.:.. |..|.||.
Worm   238 VRAPFMFMNSNPYLDYARPILTKTVLIGGISVNVTQLKQKKLNEKYDKIISERQQN-ILISFGSM 301

  Fly   296 LKTKDLP---PSKVQEILKALGGLKQRVLWKFELD------NLPNKPENVYISDWFPQTDILAHP 351
            :.:||:|   .:.:.:::|:...:  ..:||:|.|      :||    |::.|.|.|||.:||..
Worm   302 IFSKDMPDVYKNTLVQVIKSFPNV--TFIWKYEEDDVSFAKHLP----NLHFSKWVPQTALLADS 360

  Fly   352 KIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVE-FRKAIE 415
            ::.|||||.|:.|.||..|..||.:.:|:|:||..|.....::...|.|....|::.| .|.||.
Worm   361 RLSAFVTHAGLGSVTELSYMGKPAVLIPLFADQLRNSKTLSRHNGSITLSKYDLSSFEKLRFAIN 425

  Fly   416 RITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAY-----LKSAAQRLNWWQYHN 475
            .|.::..|....:.:|.:.:||   |:......|:|.  ..||.|     |...::::::..::.
Worm   426 TILNDERYKINAEILSQQLQDQ---PVSPHALLVKHA--EFGAKYGELPNLDPCSRQMSFISFYM 485

  Fly   476 VDVLLIIFVVMVLLLIVLPITIYKLLKKLLLKGERTQ 512
            :|:::.:..:::...|.:.:|:..:||....:.::.|
Worm   486 LDIIVFVGFILITTTIGIVLTVKWILKFCFKQKQKIQ 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	137/523 (26%)
ugt-33	NP_505692.2	Glycosyltransferase_GTB_type	1..498	CDD:299143	137/531 (26%)
ugt-33	NP_505692.2	UDPGT	31..520	CDD:278624	133/526 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14625
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.810