DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt-49

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_505666.2	Gene:	ugt-49 / 179446	WormBaseID:	WBGene00007070	Length:	525	Species:	Caenorhabditis elegans

Alignment Length:	545	Identity:	147/545 - (26%)
Similarity:	241/545 - (44%)	Gaps:	51/545 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FTLILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYTD 68
            :|.:..||..|...:| ..|:...|..|||......:|..||.|||  .||....:.:|:..:|.
Worm     2 YTFLFLLLSLLAVDAG-KILVYSPSISRSHLISNGRIADALVDAGH--DVVMFITEYEPLTEFTG 63

  Fly    69 VSVPNVIEVMGGDIGALWASIQKTYTQNLIDHYQMGFRITRGLFEDS---NFQDFLKSNQSFDAI 130
            .....||.:.|  ....:|.......:.|:...::.| :.|.:||.:   ...|.:...:..:.:
Worm    64 TKKAKVITMKG--FSTKFAEDMDGIGEYLLSSSRLSF-LERLMFEKTCTGACDDLMTRREELEQL 125

  Fly   131 ICETFYNDAHYGLAEHFNAPLIGLATGGGL--------TFITDMV----GSPAPASFVPHIMLPF 183
            ....|    ....:|..:...:|:....|:        |.|.|.|    |.|||:|:||.|....
Worm   126 RAYNF----DVAFSEQIDLCGVGIVRYLGIKNHLWISTTPIMDAVSYNLGIPAPSSYVPTIEEND 186

  Fly   184 N-DHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPG--NKRCFYKMRRNASLVLINQHV 245
            | |.|..::|..|: ::....:|:..|......::::::.|.  |.|   ::..|:||..:|...
Worm   187 NGDKMDFWQRTFNL-YMKIGSILIHRYGTDGTTEVFRKYIPDFPNVR---EIAANSSLCFVNSDE 247

  Fly   246 SLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINESEHGAIYFSMGSNLKTKDLPPSKVQEIL 310
            .|..|||.....|.|||:.|.....||.:|....:::.:.|.:..|:||.:...|||.:..:.:|
Worm   248 VLDLPRPTITKAIYVGGLGIPKVSKPLDKKFTNIMSKGKEGVVIISLGSIIPFGDLPAAAKEGVL 312

  Fly   311 KALGGLKQRVLWKFEL-----DNLPNK----PENVYISDWFPQTDILAHPKIMAFVTHGGMLSTT 366
            :|:..:..   :.|.:     ||...|    .:||.:::|.||.|||:||::..||.|||:....
Worm   313 RAIQEISD---YHFLIKIAKGDNNTKKLVEGIKNVDVAEWLPQVDILSHPRLKLFVMHGGINGLV 374

  Fly   367 ESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGIS 431
            |:...|.|.:.:|:|:|||.|....|:.|.|.:|....:....|:..:..:.:.|||.|....|.
Worm   375 ETAIQAVPTVIVPVFADQFRNGRMVEKRGIGKVLLKLDIGYESFKNTVLTVLNTPSYKKNAIRIG 439

  Fly   432 FRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFVVMVLLLIVLPIT 496
            ...||:..:|.|....|.:....|.....|.....|||...|:|:||:..:..|.|   .||.:.
Worm   440 KMMRDKPFSPEERLTKWTQFAIDHGVLEELHVEGSRLNTIIYYNLDVIAFVLFVFV---AVLHVF 501

  Fly   497 IYKLLKKLLLKGERTQST--KVKRN 519
            ||..  |.|...:|:||.  |.|:|
Worm   502 IYAF--KFLCCKKRSQSNIKKSKKN 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	133/502 (26%)
ugt-49	NP_505666.2	UDPGT	17..523	CDD:278624	141/527 (27%)
ugt-49	NP_505666.2	egt	<162..464	CDD:223071	89/308 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14680
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710