DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and ugt-44

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_501933.1	Gene:	ugt-44 / 177939	WormBaseID:	WBGene00008486	Length:	542	Species:	Caenorhabditis elegans

Alignment Length:	566	Identity:	131/566 - (23%)
Similarity:	240/566 - (42%)	Gaps:	102/566 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRTFTLILGLLCSLGYSSGYN-------YLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFP 58
            |.||...| ||..:.||...|       .|:.:..:|.||......:|..|...|:.:|::
Worm     1 MSTFWYAL-LLIIVYYSQTINGIERPKKVLVFMPISGHSHLKFMGTIANILQDEGYNVTLL---- 60

  Fly    59 QKKPI--PGYTDVS-----VPNVIEV--------------MGGDIGALWASIQKTYTQNLIDHYQ 102
              .||  .|..|.:     :.|.|.|              .||.....|     .....:|...:
Worm    61 --LPILDEGLRDTTPLVRKIKNRILVEQSEELIEANAQFRAGGGRENTW-----VMNSGIIGFLK 118

  Fly   103 MGFRIT-------RGLFEDSNFQDFLKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGL 160
            :|.::.       :.:|::.:..::|: :|.||..|.|..|. ..:.|.:|     :|:.|
Worm   119 LGTKVANICKASCKNVFQNEDLINYLR-DQRFDVAISEPLYT-CGFALFDH-----LGIET---- 172

  Fly   161 TFITD----------MVGSPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQE 215
            |..||          ..|:....|::|.:....::.|:|..|..|     |.....:|||   ..
Worm   173 TISTDSHLGLEVSKIAHGASISTSYLPAVFSSGSERMTLIGRAKN-----YVESYFNYYF---NS 229

  Fly   216 KLYKEFFPG------NKRCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDG--KWNPL 272
            |:|:....|      |.:.:.::.|..:.:.:|.:..:..|.|.:...||:||:. .|  |...|
Worm   230 KIYENELAGIEGIYKNGKGWRELSRKNAYMFVNSNPQMDIPSPRTSKFIEIGGIS-SGPVKQERL 293

  Fly   273 PEKIERFINESEHGAIYFSMGSNLKTKDLPPSKVQEILKALGGLKQRV-LWKFE------LDNLP 330
            ||:.:|.::..:.. :..|.|:|.|:..:.....:.::|....:.... :||:|      :....
Worm   294 PEEYDRVLSLRKKN-VLISFGTNAKSMFMSDDMKESLIKTFESMPDTTFIWKYENTTVDIVKQYN 357

  Fly   331 NKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNG 395
            .:..||.::||.|||.:||.|::..||||||:.||.|..:..||.|.:|:|.||..|....|::.
Worm   358 KRINNVMLTDWMPQTALLADPRLTLFVTHGGLGSTNEVAFSGKPSIMVPVFGDQTRNARMLERHE 422

  Fly   396 YGIML-DFKTLNAVEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAA 459
            ..::| .:...|..:.|..|.::.::.||:...:.::...|:|.::|.|..|.:...|.|.....
Worm   423 VALVLTKYDLTNFKKVRGTIRKMLNDKSYSMKAEKLAQMLRNQPESPKEIFIKYFNFVARFGKPH 487

  Fly   460 YLKSAAQRLNWWQYHNVDVLLIIFVVMVLLLIVLPITIYKLLKKLL 505
            .|.|.|..:::.:::.:|.:.|        |.:..:.:|.::.|:|
Worm   488 GLDSYAAEMSFIEFYYIDFMAI--------LSIFSVALYMIVSKVL 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	126/539 (23%)
ugt-44	NP_501933.1	UDPGT	27..510	CDD:278624	118/522 (23%)
ugt-44	NP_501933.1	egt	<250..519	CDD:223071	69/278 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860