DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and ugt-45

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_500410.2	Gene:	ugt-45 / 177139	WormBaseID:	WBGene00021372	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	549	Identity:	143/549 - (26%)
Similarity:	241/549 - (43%)	Gaps:	67/549 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIP-GYTD- 68
            |:..||..|..:|.|..|:.:...|.||......||..||:|||.:|.  :.|...||| ..|:
Worm     4 LVFLLLFVLPAASCYKILVSVPKFGFSHMQTMGKLADILVEAGHDVTF--LMPVDVPIPQNGTEL 66

  Fly    69 ---VSVPN---VIEVMG-----GDIGALWASIQKT-----YTQNLIDHYQMGFRITRGLFEDSNF 117
               |.||.   :.|:||     |.:..||.....:     ::.::|.  |:.:..|:.|.::...
Worm    67 AKVVLVPTTDAINEIMGHAMKSGAVANLWTHSANSKQGIMWSTDMIG--QVSYHNTKNLIDNKAL 129

  Fly   118 QDFLKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGL--ATGGGLTFITD----MVGSPAPASFV 176
            ...:| ::.||..|.|.|   ...||| .|.  :|||  ..|...|.:.:    ..|:|...|||
Worm   130 VQQMK-DEKFDIGITELF---DFSGLA-FFE--VIGLKNVMGAHTTSVFEGTLMATGAPILPSFV 187

  Fly   177 PHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLP-----TQEKLYKEFFPGNKRCFYKMRRNA 236
            |......:|..|:..||.|: ::.|    ..|.|..     .|:.|.:.:..|.....:.:..:.
Worm   188 PASQTFTDDSGSILSRLNNL-YMTY----WSYQFQNKIQSFAQKALDEHYEKGKAPKIWNLVSDI 247

  Fly   237 SLVLINQHVSLSFPRPHSPNMIEVGGMHID-----GK-WNPLPEKIERFINESEHGAIYFSMGSN 295
            :...:|......||:|...|::|:.|:.:.     || |:.:..|..:        .:..|.||.
Worm   248 TWFFVNSDPIFDFPKPLPQNIVEIAGISVPEIKPVGKEWDEILSKRSK--------NVLVSFGSI 304

  Fly   296 LKTKDLPPSKVQEILKALGGLKQ-RVLWKFELDNLPNK----PENVYISDWFPQTDILAHPKIMA 355
            .....:|.:..:.|:.|...... ..:||:  |:..:|    .:||:|..|.||.|:||..:|..
Worm   305 ASPTTMPEAVKKSIVDAFAAFPDVTFIWKY--DDTESKLTAHLDNVHIVKWMPQNDLLADKRISM 367

  Fly   356 FVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTL-NAVEFRKAIERITS 419
            |.|||||.|..||...:.|::.:|||.||..|...|:::|..::.|...| |..:...|::.:..
Worm   368 FWTHGGMGSLMESAQKSVPLVVVPIFGDQMRNAQIAKRHGVALIYDKMDLSNTKKLIGALKEVLE 432

  Fly   420 EPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFV 484
            .|.|.|..:.::.....::.:|.:..|..||...|........||.:..::.:|.|:|:::|...
Worm   433 NPEYKKSAELLARILATERFSPRQKIIDTVEMAGRFGQMPRWTSAGKEFSFLKYFNLDLVIIAVF 497

  Fly   485 VMVLLLIVLPITIYKLLKKLLLKGERTQS 513
            :..|.::...:.|..||.||...|::.:|
Worm   498 IFFLSIVSTVLLIRHLLAKLGFSGDKEKS 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	134/514 (26%)
ugt-45	NP_500410.2	egt	14..513	CDD:223071	133/524 (25%)
ugt-45	NP_500410.2	UDPGT	19..510	CDD:278624	130/516 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14613
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860