DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt-58

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_496059.2	Gene:	ugt-58 / 174507	WormBaseID:	WBGene00009450	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	550	Identity:	126/550 - (22%)
Similarity:	228/550 - (41%)	Gaps:	70/550 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRTFTLILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPG 65
            |:::.|:||   ::|:.:..:.|.:.::....|......||:.|.:.||.:|.:.:.|::..|..
Worm     1 MKSWLLLLG---TIGWVTAGDVLFIPSTLYPVHAQTMSVLARELAERGHKVTWLEIGPERSDIVL 62

  Fly    66 YTDVSVPNVIEVMGGDIGALW------ASIQKTYT-QNLIDHYQM-----------------GFR 106
            :..||            ...|      .::|:.|. :|...|.::                 ..|
Worm    63 HQQVS------------REFWPAQFGDRTLQEIYQFKNHTSHSELWNPQYTNENEQTTGWLASIR 115

  Fly   107 ITRGLFEDSNFQDFLKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGG---GLTFITDMVG 168
            :...:...|..:......:.|..:|.:..||..             |:...|   .:.....|.|
Worm   116 LCDSVLSRSKSKFDKMVEKQFSTVIVDDLYNSC-------------GVLMAGLKKSVYIYWSMTG 167

  Fly   169 ----------SPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFP 223
                      ||:|.|::|.......|.::..:||.|||....:..:..:...|..:.::::::|
Worm   168 LRTESAWANQSPSPPSYLPVAGTGLTDDLTFSQRLYNVASYFKQLYIHQHIVQPRIDAVFQKYYP 232

  Fly   224 GNKRCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINESEHGAI 288
            |.:..| ::.||||:..:|......|.||:.|.:..:|.:.. .|...||::...:|:....|.:
Worm   233 GVESTF-EIERNASINFVNTPPIFDFSRPYMPRVNFIGAIQC-RKPKELPKEFTSWISAYPDGFV 295

  Fly   289 YFSMGSNLKTKDLPPSKVQEILKALGGLKQRV-LWKFELDNLPNKPENVYISDWFPQTDILAHPK 352
            ..|.|..::....|....|..|.....|...: :|:..|.|..|.|.|:.:..|.|..|:|.|.|
Worm   296 VLSTGFTVQWNKSPEHIRQAYLDTFKYLPNLLFIWQTGLPNSSNLPSNLLVKPWLPLQDLLGHQK 360

  Fly   353 IMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERI 417
            ....|:|||:.|..||:||..||:|:|:.|..:.|:........|:|::....:......||..:
Worm   361 CRCHVSHGGLNSVIESVYHGVPVVGVPLTSRGYDNLLRITARDSGVMVEKSEFSGEILTAAINEV 425

  Fly   418 TSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLII 482
            .....|.|.:........|...|.:.:|.:|||.:.|||...:.:|.|..||:.||..|||:...
Worm   426 IENEKYKKEMLIFQDMVIDVPYTELYHAAFWVEFIERHQEVPHARSGADHLNFLQYFLVDVIAFF 490

  Fly   483 FVVMVLLLIVLPITIYKLLKKL--LLKGER 510
            |.|:...|.::..||..:.:.:  ::.|.|
Worm   491 FFVIFCTLSIIYYTIRTVFRTIRSVVNGVR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	119/516 (23%)
ugt-58	NP_496059.2	UDPGT	17..485	CDD:278624	111/494 (22%)
ugt-58	NP_496059.2	Glycosyltransferase_GTB_type	<200..462	CDD:299143	69/263 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	180	1.000	Domainoid score	I2087
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14290
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.710