DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt-25

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_491438.1	Gene:	ugt-25 / 172087	WormBaseID:	WBGene00015692	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	131/563 - (23%)
Similarity:	234/563 - (41%)	Gaps:	109/563 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYTDVSVPNV 74
            :|.|:...:.:|.|:...|.|.||.|....||..|.:|||.:|.|                ||..
Worm     8 ILLSVINVNAFNILVYSPSFGGSHTNFMARLADTLTEAGHNVTFV----------------VPVA 56

  Fly    75 IEVMGGDIGALWASIQKTYTQNLIDHYQMGFRITRGLFED------------------SNFQD-- 119
            .|...|.:|     ::||....:::..::.....:.|.:|                  |.|.|
Worm    57 DEARKGQLG-----VKKTKDVVIVEQDELMKSEIKPLDDDMAQYWETDMDSSNADSIFSVFSDAM 116

  Fly   120 ------FLKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFI------------TDM 166
                  |:::.:.|:.:....|    ..|:.|..:...:|.....|:..:            ...
Worm   117 LLSCNNFMRNKKVFNELKSRNF----DVGIYEPLSVCGLGYMHAIGINKLIMSSSCALYDGTVAA 177

  Fly   167 VGSPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYK 231
            :|.|...|:||..|....:.|||:|:|.|.. |......:.|.....:.::||:....:...:..
Worm   178 IGEPIDFSYVPGSMSKSGEKMSLFEKLENYR-LSMASSRMQYGQWDKETEIYKKHLGNDIPHWRD 241

  Fly   232 MRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDG---KWNPLPEKIERFINESEHGAIYFSMG 293
            :..::|:...|....:.|||..:...:.:||:.:|.   |...|..:....::|..|..: .|.|
Worm   242 LMPSSSVAFTNSIPYVDFPRSITQKTVPIGGISVDMEMIKSQKLSIEWSTVLDERPHNML-ISFG 305

  Fly   294 SNLKTKDLPPSKVQEILKALGGLKQRV--------LWKFELDNL--PNKPENVYISDWFPQTDIL 348
            |.:::.|:|       ||...||.:.:        :||:|.|||  ....:|:|.|.|.|||.:|
Worm   306 SMVRSMDMP-------LKWRNGLLEAIKSEPNVTFIWKYENDNLEWAKGIQNIYFSKWVPQTALL 363

  Fly   349 AHPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIML-------DFKTLN 406
            ...::.||:||||:.||.|..:..||.:.:|:|:||..|.....::| |:::       :|||:
Worm   364 NDARLTAFMTHGGLGSTNELAFLGKPALMVPVFADQDRNANMLARHG-GVLVVHKKELGNFKTI- 426

  Fly   407 AVEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWW 471
                :.:|..|..|..|.|..:.:|....:|...|.|..:.:.|.|.:......:.|..::|.:.
Worm   427 ----KSSIRSILHEEKYQKNARKLSELLNNQPLKPKEQVVKYTEFVAKFGPFPQMDSYGRQLGFI 487

  Fly   472 QYHNVD-----------VLLIIFVVMVLLLIVLPITIYKLLKK 503
            |.:.:|           |:.:|:.|...::...|:.:.||:||
Worm   488 QRNLIDIYAAISLSYLFVISLIYFVFKFVISKTPLKLVKLVKK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	124/538 (23%)
ugt-25	NP_491438.1	egt	1..477	CDD:223071	119/508 (23%)
ugt-25	NP_491438.1	UDPGT	29..530	CDD:278624	123/540 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860