DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt-26

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_491435.2	Gene:	ugt-26 / 172085	WormBaseID:	WBGene00015695	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	527	Identity:	138/527 - (26%)
Similarity:	240/527 - (45%)	Gaps:	44/527 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTIT--VVSVFPQKKPIPGY---TDV 69
            :||:|...|..|.|:...:...||.|....||..|.:|||.:|  |.....:::...|.   .||
Worm    12 VLCTLSLVSSLNILVHSPAYAASHTNFMARLADTLTEAGHNVTFLVPIALEERRDKLGVKLTKDV 76

  Fly    70 SVPNVIEVM-------GGDIGALW------ASIQKTYTQNLIDHYQMGFRITRGLFEDSNFQDFL 121
            .:....|.|       .|.|..||      :||...::.    :.::..........:......|
Worm    77 IIVEQDEEMKSKLVPHSGSIEFLWIIEMDSSSIDAMFSW----YNEIMILTCENFMRNKQVMSEL 137

  Fly   122 KSNQSFDAIICETFYNDAHYGLAEHFN-APLIGLATGGGLTFITDMVGSPAPASFVPHIMLPFND 185
            || :.||..|.|.| .....||.|..| ...|.:::.....|:...:|.|...|.||.:.....:
Worm   138 KS-RHFDVAIAEPF-TICGLGLFEELNIKKTILVSSCAHYDFMLPHIGEPEDFSSVPTLSSKVGE 200

  Fly   186 HMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRRNASLVLINQHVSLSFP 250
            .||:.|:..|...:...:..|...| ..:.::|:|.|..:...:.::..:|||...|.:..:.:|
Worm   201 EMSMTEKWENYRLVAETKASLAKLF-DAETRIYRESFGSDIPDWKELMSSASLYFTNSNPFIDYP 264

  Fly   251 RPHSPNMIEVGGMHIDG---KWNPLPEKIERFINESEHGAIYFSMGSNLKTKDLP---PSKVQEI 309
            |......|.:||:.:|.   |...|.::.|..:|:.:. ::..|.|||:.:..:|   .:.:.|.
Worm   265 RASIQKTISIGGITVDFQQIKSEKLNKEWEEVLNKRQK-SMLISFGSNVPSDKMPAAWKAGIFET 328

  Fly   310 LKALGGLKQRVLWKFELDNL--PNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESIYHA 372
            :|::..:  ..:||:|.|::  .:...|::.|.|.|||.:|..|::.||:||||:.||.|..|.|
Worm   329 IKSMPNV--TFIWKYESDDVSFADGISNIHFSKWVPQTALLNDPRLSAFLTHGGLGSTNELAYCA 391

  Fly   373 KPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTL-NAVEFRKAIERITSEPSYTKVVQGISFRYRD 436
            ||.:.:||:.||..|.....::|..|:|..|.| |....:||:..|.....||:..:.|:...::
Worm   392 KPAVMVPIYGDQTRNANMLARHGSVIVLHKKELANVQRVKKAVHDILYNKQYTESAERIAEMIKN 456

  Fly   437 QQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDV--LLIIFVVMVL----LLIVLPI 495
            |.:||.|..:.:.|.|.::.....:....::|.::|...:|:  |..:.||.||    |:|...:
Worm   457 QPKTPKETVVRYTEFVAKYGPFPQMAPHGRKLTYFQKTFLDIYSLFALGVVSVLTVAFLVIRYVL 521

  Fly   496 TIYKLLK 502
            :.:||.|
Worm   522 SCFKLKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	128/499 (26%)
ugt-26	NP_491435.2	egt	4..481	CDD:223071	125/478 (26%)
ugt-26	NP_491435.2	UDPGT	34..525	CDD:278624	129/500 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14289
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860