DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_569091.2	Gene:	Ugt1a7c / 154516	RGDID:	620950	Length:	531	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	160/545 - (29%)
Similarity:	272/545 - (49%)	Gaps:	56/545 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TLILGLLCSLGYSSGYNY---LMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQ-----KK 61
            :|.|| ||.| .:||:.:   |:|:...| ||:.....:.:.|:..||.:.|  |.|:     .|
  Rat     9 SLPLG-LCLL-LASGFGHAGKLLVVPMDG-SHWFTMQMVVEKLLPKGHEVVV--VVPEVSWQLGK 68

  Fly    62 PIPGYT--DVSVPNVIEVMGGD----IGALWASIQK-----TYTQNLIDHYQMGFRITRGLFEDS 115
            |: .:|  ..||.:..|.:..:    |.:.|.:.|:     ..|......:::.|...|.||:|.
  Rat    69 PL-NFTVKTYSVSHTQEDLNREFKFFIDSQWKTQQEGGVLPLLTSPAQGFFELLFSHCRSLFKDK 132

  Fly   116 NFQDFLKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGSPAPASFVPHIM 180
            ...::||.: ||||:..:.| :.....:|::|:.|.:..:.|....::.:....|:|.|:||..:
  Rat   133 KLVEYLKQS-SFDAVFLDPF-DVCGLTVAKYFSLPSVVFSRGIFCHYLEEGSQCPSPPSYVPRGI 195

  Fly   181 LPFNDHMSLYERLLN-VAFLGYERVLLDYYF----------LPTQEKLYKEFFPGNKRCFYKMRR 234
            |...|.|:..||:.| ::::| |......:|          |.|...:...|.|
  Rat   196 LKLTDTMTFKERVWNLLSYMG-EHAFCPSFFKTATDIASEVLQTPVTMTDLFSP----------- 248

  Fly   235 NASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKT 298
             .|:.|:....:|..|||..||:|.:||::...: .||.::.|.::|.| |||.:.||:||  ..
  Rat   249 -VSVWLLRTDFTLELPRPVMPNVIHIGGINCHQR-KPLSKEFEAYVNASGEHGIVVFSLGS--MV 309

  Fly   299 KDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGML 363
            .::|..|..||.:|||.:.|.|||::......|..:|..:..|.||.|:|.|||..||:||.|..
  Rat   310 SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSH 374

  Fly   364 STTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQ 428
            ...|.|.:..|::.:|:|.||..|....|..|.|:.|:...:.|.:...|::.:.:..||.:.:.
  Rat   375 GIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIM 439

  Fly   429 GISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-LIIFVVMVLLLIV 492
            .:|..::|:...|::.|::|||:|.||:||.:|:.||..|.|:|||::||: .::.:|:.::.||
  Rat   440 RLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIV 504

  Fly   493 LPITIYKLLKKLLLKGERTQSTKVK 517
            .....|...|....||...:|.|.|
  Rat   505 YKSCAYGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	150/506 (30%)
Ugt1a7c	NP_569091.2	UDPGT	26..522	CDD:278624	149/517 (29%)
Ugt1a7c	NP_569091.2	egt	<264..505	CDD:223071	85/243 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136043
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860