DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	164/543 - (30%)
Similarity:	262/543 - (48%)	Gaps:	90/543 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LMVLNSAGRSHFNVGHALAKGLVKAGHTITVV----------SVFPQKKPIPGYTDVSVPNVIEV 77
            |:|:...| ||:.....:.:.|.:.||.|.|:          |.:.::|..|      ||..:|.
  Rat    28 LLVVPQDG-SHWLSMKEIVEHLSERGHDIVVLVPEVNLLLGESKYYRRKSFP------VPYNLEE 85

  Fly    78 M-------GGDIGA----LWASIQKTYTQNLIDHYQMGFRITRGLFEDSNFQDFLKSNQSFDAII 131
            :       |.:..|    |.|.::: |..|:| ...|.|...:.|.:||....||:.|| |||:.
  Rat    86 LRTRYRSFGNNHFAASSPLMAPLRE-YRNNMI-VIDMCFFSCQSLLKDSATLSFLRENQ-FDALF 147

  Fly   132 ------CETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVG-SPAPASFVPHIMLPFNDHMSL 189
                  |...       |||:...|.:.|..|...: :..|:| ||:|.|:||.....|:|||:.
  Rat   148 TDPAMPCGVI-------LAEYLKLPSVYLFRGFPCS-LEHMLGQSPSPVSYVPRFYTKFSDHMTF 204

  Fly   190 YERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYK---------MRRNASLVLINQHV 245
            .:||.|  |:.  .:|.:|.:                .|.|.         ::|:.||..::|:
  Rat   205 PQRLAN--FIA--NILENYLY----------------HCLYSKYEILASDLLKRDVSLPALHQN- 248

  Fly   246 SL---------SFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKD 300
            ||         .:|||..||||.:||.:...|.| |.::.|.::|.| |||.:.||:||  ...:
  Rat   249 SLWLLRYDFVFEYPRPVMPNMIFIGGTNCKKKGN-LSQEFEAYVNASGEHGIVVFSLGS--MVSE 310

  Fly   301 LPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLST 365
            :|..|..||.:|||.:.|.|||::......|..:|..:..|.||.|:|.|||..||:||.|....
  Rat   311 IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGI 375

  Fly   366 TESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGI 430
            .|.|.:..|::.:|:|.||..|....|..|.|:.|:...:.|.:...|::.:.:..||.:.:..:
  Rat   376 YEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRL 440

  Fly   431 SFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL-LIIFVVMVLLLIVLP 494
            |..::|:...|::.|::|||:|.||:||.:|:.||..|.|:|||::||: .::.:|:.::.||..
  Rat   441 SSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYK 505

  Fly   495 ITIYKLLKKLLLKGERTQSTKVK 517
            ...|...|....||...:|.|.|
  Rat   506 SCAYGCRKCFGGKGRVKKSHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	154/504 (31%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	156/517 (30%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	161/534 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860