Protein Alignment Ugt302K1 and UGT2A1

DIOPT Version :10

• Sequence 1: NP_652620.1
• Gene: Ugt302K1 / 53502
• FlyBaseID: FBgn0040251
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 147/512 - (28%)
• Similarity: 244/512 - (47%)
• Gaps: 86/512 - (16%)

  Fly    32 SHFNVGHALAKGLVKAGHTITVV----SVFPQKKP--------IP-GYTDVSVPNVIEVMGGDIG 83
            ||:.....:.:.|::..|.:||:    ::|....|        || .|...::.::||.|    .
Human   241 SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHM----I 301

  Fly    84 ALWASIQKT-------YTQ--NLID-HYQMGFRITRGLFEDSNFQDFLKSNQSFDAIICE--TFY 136
            .||...:.|       |.:  .|:| .:|:..::..|:.::......|:.. .||.::.:  |..
Human   302 MLWIDHRPTPLTIWAFYKELGKLLDTFFQINIQLCDGVLKNPKLMARLQKG-GFDVLVADPVTIC 365

  Fly   137 NDAHYGLAEHFNAPLIGLATGGGLTFITDMVGS------------PAPASFVPHIMLPFNDHMSL 189
            .|            |:.|..  |:.|:..:..|            |||.|:||..:....|.|:.
Human   366 GD------------LVALKL--GIPFMYTLRFSPASTVERHCGKIPAPVSYVPAALSELTDQMTF 416

  Fly   190 YERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFY-----------KMRRNASLVLINQ 243
            .||:.|.  :.|.  |.||.|         :.:.|....:|           :....|.:.||..
Human   417 GERIKNT--ISYS--LQDYIF---------QSYWGEWNSYYSKILGRPTTLCETMGKAEIWLIRT 468

  Fly   244 HVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKDLPPSKVQ 307
            :....||||:.||...|||:|.... .|||:::|.||..| ::|.:.||:||  ..|:|...|..
Human   469 YWDFEFPRPYLPNFEFVGGLHCKPA-KPLPKEMEEFIQSSGKNGVVVFSLGS--MVKNLTEEKAN 530

  Fly   308 EILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESIYHA 372
            .|..||..:.|:|||:::.........|..:.||.||.|:|.|||..||:||||.....|:|||.
Human   531 LIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHG 595

  Fly   373 KPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGISFRYRDQ 437
            .|::|:|:|:||..|:||.:..|..:.::..|:.:|:...|:..:.:||||.:....:|..:.||
Human   596 VPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQ 660

  Fly   438 QQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL--LIIFVVMVLLLIV 492
            ...|::.|::|:|.|.||:||.:|:.||..|.|:|||::||:  |::.|...:.|::
Human   661 PVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVI 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_652620.1	GT1_Gtf-like	24..448	CDD:340817	127/464 (27%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	147/512 (29%)