DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and UGT2A1

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001376494.1	Gene:	UGT2A1 / 10941	HGNCID:	12542	Length:	737	Species:	Homo sapiens

Alignment Length:	512	Identity:	147/512 - (28%)
Similarity:	244/512 - (47%)	Gaps:	86/512 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SHFNVGHALAKGLVKAGHTITVV----SVFPQKKP--------IP-GYTDVSVPNVIEVMGGDIG 83
            ||:.....:.:.|::..|.:||:    ::|....|        || .|...::.::||.|    .
Human   241 SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHM----I 301

  Fly    84 ALWASIQKT-------YTQ--NLID-HYQMGFRITRGLFEDSNFQDFLKSNQSFDAIICE--TFY 136
            .||...:.|       |.:  .|:| .:|:..::..|:.::......|:.. .||.::.:  |..
Human   302 MLWIDHRPTPLTIWAFYKELGKLLDTFFQINIQLCDGVLKNPKLMARLQKG-GFDVLVADPVTIC 365

  Fly   137 NDAHYGLAEHFNAPLIGLATGGGLTFITDMVGS------------PAPASFVPHIMLPFNDHMSL 189
            .|            |:.|..  |:.|:..:..|            |||.|:||..:....|.|:.
Human   366 GD------------LVALKL--GIPFMYTLRFSPASTVERHCGKIPAPVSYVPAALSELTDQMTF 416

  Fly   190 YERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFY-----------KMRRNASLVLINQ 243
            .||:.|.  :.|.  |.||.|         :.:.|....:|           :....|.:.||..
Human   417 GERIKNT--ISYS--LQDYIF---------QSYWGEWNSYYSKILGRPTTLCETMGKAEIWLIRT 468

  Fly   244 HVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKDLPPSKVQ 307
            :....||||:.||...|||:|.... .|||:::|.||..| ::|.:.||:||  ..|:|...|..
Human   469 YWDFEFPRPYLPNFEFVGGLHCKPA-KPLPKEMEEFIQSSGKNGVVVFSLGS--MVKNLTEEKAN 530

  Fly   308 EILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESIYHA 372
            .|..||..:.|:|||:::.........|..:.||.||.|:|.|||..||:||||.....|:|||.
Human   531 LIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHG 595

  Fly   373 KPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGISFRYRDQ 437
            .|::|:|:|:||..|:||.:..|..:.::..|:.:|:...|:..:.:||||.:....:|..:.||
Human   596 VPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQ 660

  Fly   438 QQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVL--LIIFVVMVLLLIV 492
            ...|::.|::|:|.|.||:||.:|:.||..|.|:|||::||:  |::.|...:.|::
Human   661 PVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVI 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	144/498 (29%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	147/512 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150208
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.690