DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt5b2

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001170970.2	Gene:	ugt5b2 / 100415799	ZFINID:	ZDB-GENE-100406-4	Length:	531	Species:	Danio rerio

Alignment Length:	533	Identity:	141/533 - (26%)
Similarity:	242/533 - (45%)	Gaps:	87/533 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SHFNVGHALAKGLVKAGHTITVVSVFPQ---KKPIPGYTDVSVPN-------VIEVMGGDI---- 82
            ||:...:.|.:.|...||.:||:.....   |:..|.||.:::.:       |:|.....|
Zfish    37 SHWVNMNILVEALSAKGHDVTVMRTASSCYIKEFSPHYTSINLKSKGGYNKEVLEQFASRIMHIL 101

  Fly    83 --GALWA--SIQKTYTQNLIDHYQMGFRITRGLFEDSNFQDFLKSNQSFDAIICE---------- 133
              |:.|.  .:|....|:.:..::....:...:.||......|| :..:|.|:.:
Zfish   102 RDGSTWGHLKLQADMWQSFLKIFEAEREMIVNMIEDQQLMQSLK-DAKYDLILTDPNMFGGVILG 165

  Fly   134 -------------TFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGSPAPASFVPHIMLPFND 185
                         ..||:||:.:|                         |:|.|:||...|..:|
Zfish   166 HYLKLPMVYNVRWAGYNEAHFSIA-------------------------PSPLSYVPMPSLELSD 205

  Fly   186 HMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFF-PGNKRCFYKMRRNASLVLINQHVSLSF 249
            .||..:|:.||....:..:.......|..:.|.:.|. ||..  |..:.:.|.|.|........:
Zfish   206 RMSFLQRVYNVVMYIFIEIGAALVISPINDALAERFIGPGTS--FLSLVQGADLWLHRVDFVFEY 268

  Fly   250 PRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKDLPPSKVQEILKAL 313
            |||..||:|.:.|...... .|||:.:|.|:..| :||.|..|:|:.:  ..||....:.|.:|.
Zfish   269 PRPTMPNVIYMAGFQCKPS-KPLPQDLEDFVQSSGDHGVIIMSLGTLI--DKLPDDVAEAIAEAF 330

  Fly   314 GGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESIYHAKPVIGL 378
            ..|.|:::|:::.........|..|.||.||.|:|.|||..|||.|||.....|:|||..|:||.
Zfish   331 AELPQKIIWRYKGKRPSALGNNTLIMDWMPQNDLLGHPKTRAFVAHGGTNGIQEAIYHGVPIIGF 395

  Fly   379 PIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIE 443
            .:..||..|::.....|....:||.|:|...|...::.:..:|||.:.:|.:|..::|....|::
Zfish   396 GLIFDQPDNLSKMRVRGAAKNVDFATMNKESFLTTVKEVLYDPSYRENMQRLSRLHKDVPVKPLD 460

  Fly   444 NAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFVVMVLLLIVLPITIYKLLK----KL 504
            |||:|:|.|.||:|||:|::.:.::.|:.||:|||:|::...:.|::    ::||.:::    ::
Zfish   461 NAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVILVLISAVSLII----LSIYAVIRYFCCRI 521

  Fly   505 LLKGERTQSTKVK 517
            .::     .||:|
Zfish   522 CMR-----KTKIK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	134/490 (27%)
ugt5b2	NP_001170970.2	egt	12..501	CDD:223071	135/494 (27%)
ugt5b2	NP_001170970.2	UDPGT	27..525	CDD:278624	138/527 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584551
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790