DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt5d1

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001170967.1	Gene:	ugt5d1 / 100415794	ZFINID:	ZDB-GENE-091118-36	Length:	532	Species:	Danio rerio

Alignment Length:	563	Identity:	162/563 - (28%)
Similarity:	260/563 - (46%)	Gaps:	85/563 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRTF----TLILGLLC-----SLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVS- 55
            |::|    .:|.||..     :|..|.|   .::|.....||:.....|.:.|...||:|||:.
Zfish     1 MKSFFSQSNVITGLFLALSAFTLSCSGG---KILLYPVDGSHWVNMKVLIEELHSRGHSITVIRP 62

  Fly    56 ----VFPQKKPIPGYTDVSVPN---------------VIEVMGGD-IGALWASIQKTYTQNLIDH 100
                ...:|.|:  ||.:::.:               .:|:..|: .|..:..:|......|...
Zfish    63 KSSWYITEKSPL--YTSITIQDNVNDFENFFEDYLSKAMEIERGEGSGLAFLKLQYDLFSMLSTA 125

  Fly   101 YQMGFRITRGLFEDSNFQDFLKSNQSFDAIICETFYNDAHYGLAEHFNAPLI----GLATGGGLT 161
            :::..::...:.||......|:..| :|.::.:.......: ||.:...||:    .:.:|.|..
Zfish   126 HEIACKMVSIILEDKMLVKKLQDEQ-YDLMLTDPAIAGGVF-LAHYLKLPLVLNVRWITSGEGHF 188

  Fly   162 FITDMVGSPAPASFVPHIMLPFNDH---MSLYERLLNVAFLGYE------------RVLLDYYFL 211
            .|     :|:|.|::|   ||.:.|   |...:|:.||.|..:.            .:|:|.|.
Zfish   189 AI-----APSPMSYIP---LPGSGHTDKMGFAQRVKNVLFKTFTFLQNRFVVGPHYDILIDKYL- 244

  Fly   212 PTQEKLYKEFFPGNKRCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKI 276
                 .||....|       :.:.|.:.|:.......||||..||::.:||...... .|||..:
Zfish   245 -----DYKTDIVG-------LIQAADIWLMRADFVFEFPRPTMPNIVYMGGFRCKPS-KPLPADL 296

  Fly   277 ERFINES-EHGAIYFSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISD 340
            |.|...| |||.|..|:|:.:|:  ||......|..|...|.|:|:|:...|...|...|..|.|
Zfish   297 EAFAQSSGEHGFIIMSLGTLVKS--LPADMANAIAAAFARLPQKVIWRHLGDRPSNVGNNTLIVD 359

  Fly   341 WFPQTDILAHPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTL 405
            |.||.|:|.|.||.|||.|||.....|:|:|..||:|:|:|.|||.|:...:..|.|.:|....|
Zfish   360 WMPQNDLLGHSKIKAFVAHGGTNGVQEAIFHGVPVLGVPLFFDQFDNLIRVQGKGAGKILKLSEL 424

  Fly   406 NAVEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNW 470
            ||..|.:|:....::.||.:.:|.:|..:|||...|::.||:|:|||.||:||.:|:|...::.|
Zfish   425 NAEAFEQALRESLNDGSYKRNMQTLSTLHRDQPMRPLDTAIFWIEHVIRHKGATHLRSEFYKMPW 489

  Fly   471 WQYHNVDVLLIIFVV----MVLLLIVLPITIYKLLKKLLLKGE 509
            :.||:|||.|::|:|    |:..:.|:....||:..:...|.|
Zfish   490 YSYHSVDVFLVLFIVAAVCMLSTIAVIRYVCYKICCRRKSKSE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	153/528 (29%)
ugt5d1	NP_001170967.1	UDPGT	28..527	CDD:278624	153/529 (29%)
ugt5d1	NP_001170967.1	egt	<267..506	CDD:223071	97/241 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585159
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690