DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and ugt5c1

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001170966.1	Gene:	ugt5c1 / 100415793	ZFINID:	ZDB-GENE-050419-68	Length:	531	Species:	Danio rerio

Alignment Length:	551	Identity:	157/551 - (28%)
Similarity:	265/551 - (48%)	Gaps:	76/551 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TFTLILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVV----SVFPQKKPI 63
            |..:|.|.||..|      .::|....| ||:.....|.|.|...|||:.|:    |.| .|:..
Zfish    16 TVMIIFGSLCDGG------KILVAPLEG-SHWVNMDILIKALHGQGHTVDVIRNTNSWF-VKENS 72

  Fly    64 PGYTDVSVPN--------VIEVM----------GGDIGA--LWASIQKTYTQNLIDHYQMGFRIT 108
            ..|..:::|:        |.:|:          |..:|.  |:..:.|.    :.:.:::..|:.
Zfish    73 TYYNSITIPDSKGMDEEFVEDVLTKKIDYERGKGSWLGGVQLFLDVSKA----VYESHKLVCRLI 133

  Fly   109 RGLFEDSNFQDFLKSNQ--SFDAIICETFYNDAHYG----LAEHFNAPLIGLATGGGLTFITDMV 167
            ..:||.   :|.||:.|  .:|.::     .|..:|    ||.....|::     ..:.:.|...
Zfish   134 TNIFES---EDILKALQEKKYDLML-----TDPGWGTGIILAHKLKLPMV-----YNVRWTTPGE 185

  Fly   168 G----SPAPASFVPHIMLPFNDHMSLYERLLNVAFLGYERVLLDY----YFLPTQEKLYKEFF-- 222
            |    :|:|.|::|.......|.||.::|::||.:.    :|||:    :.:|..:.|..::|
Zfish   186 GHFDIAPSPMSYIPLTGSGNTDKMSFFQRVINVFYY----LLLDFQCSRFNVPQYQALCDKYFDP 246

  Fly   223 PGNKRCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHG 286
            |.:   |||:.:.|.|.|:.......||||..||:|..||.... ...|||..:|.|:..| :||
Zfish   247 PVD---FYKLLQGADLWLMRVDFVFEFPRPTMPNIIYTGGFQCT-PTKPLPHDLEDFMQSSGDHG 307

  Fly   287 AIYFSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHP 351
            .|..|:||.:..  ||.....||..|...|.|:|:|::..........|..:.||.||.|:|.||
Zfish   308 VIVMSLGSFISV--LPDYVSSEIAAAFARLPQKVIWRYTGKKPSTLGNNTLLVDWMPQKDLLGHP 370

  Fly   352 KIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIER 416
            |...|:.|||.....|::||..||||:|.|.||:.|:...:..|...::....|.......||:.
Zfish   371 KTKLFIAHGGTNGVQEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIQE 435

  Fly   417 ITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLI 481
            :.:||||...:|.:|:.:||:...|:::||:|:|.|.||:|||:|::.:.::.|:.||:|||.:.
Zfish   436 VINEPSYRLNMQKLSYLHRDKPVEPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVSVT 500

  Fly   482 IFVVMVLLLIVLPITIYKLLKKLLLKGERTQ 512
            :..|:::.:..:.:|:..|..|...:..:|:
Zfish   501 LIAVVLIFIYSMFVTVRYLCIKCCSRKRKTE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	152/517 (29%)
ugt5c1	NP_001170966.1	UDPGT	28..530	CDD:278624	151/536 (28%)
ugt5c1	NP_001170966.1	egt	<267..507	CDD:223071	87/242 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585111
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690