DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt302K1 and ugt5b3

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001348442.1	Gene:	ugt5b3 / 100415792	ZFINID:	ZDB-GENE-100406-5	Length:	534	Species:	Danio rerio

Alignment Length:	519	Identity:	149/519 - (28%)
Similarity:	246/519 - (47%)	Gaps:	57/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SHFNVGHALAKGLVKAGHTITVVSVFPQ---KKPIPGYTDVSV------------PNVIEVM--- 78
            ||:...:.|.:.|...||.|||:.:...   |:..|.||.|::            |.|..:|
Zfish    37 SHWVNMNVLVEALHAKGHNITVMRMADSWYIKEFSPHYTSVNLKSSGGLSEDFIGPFVSRLMNIL 101

  Fly    79 --GGDIGALWASIQKTYTQNLIDHYQMGFRITRGLFEDSNFQDFLKSNQSFDAIICETFYNDAHY 141
              |...|.|...|:...|.  :...::...:...:.||......|| ...||.|:.:    .|.|
Zfish   102 REGSTWGRLKLEIEMWQTS--LKMIEIEREMITNMIEDQQLMQSLK-KAKFDLILTD----PAMY 159

  Fly   142 G---LAEHFNAPLI----GLATGGGLTFITDMVGSPAPASFVPHIMLPFNDHMSLYERLLNVAFL 199
            |   |..:...|::    ....|.|...|     :|:|.|:||..||...|.||..||:.||...
Zfish   160 GGVMLGHYLKLPIVYNVRWTIFGEGHFAI-----APSPLSYVPVPMLEIPDRMSFLERVKNVVMY 219

  Fly   200 GYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRRNASLVLINQHVSLSFPRPHSPNMIEVGGMH 264
            ......:.:...||...|.:.|. |.:..|..:.:.|.|.|........:|||..||::.:.|..
Zfish   220 IITETQIAFLIAPTYNALCERFI-GPEVNFGNLVQEADLWLHRADFVFEYPRPTMPNIVYMAGFQ 283

  Fly   265 IDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKDLPPSKVQEILKALGGLKQRVLWKFELDN 328
            .... .|||:.:|.|:..| :||.|..|:|:.:  ..||....:.|.:|...|.|:::|:::...
Zfish   284 CKPS-KPLPQDLEDFVQSSGDHGVIVMSLGTLI--GQLPDDVAEAIAEAFAELPQKIIWRYKGKR 345

  Fly   329 LPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESIYHAKPVIGLPIFSDQFFNMAHAEQ 393
            ......|..:.||.||.|:|.|||..|||.|||.....|:|||..|:||..:..||..|::....
Zfish   346 PSALGNNTLVMDWMPQNDLLGHPKTRAFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRV 410

  Fly   394 NGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGISFRYRDQQQTPIENAIYWVEHVTRHQGA 458
            .|....:||.|::...|.|.::.:..:|||.:.:|.:|..::|....|::|||:|:|.|.||:||
Zfish   411 RGAAKNVDFATMDKESFLKTVKEVLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGA 475

  Fly   459 AYLKSAAQRLNWWQYHNVDVLLIIFVVMVLLLIVLPITIYKLLK----KLLLKGERTQSTKVKR 518
            |:|::.:.::.|:.||:|||:|::...:.|::    ::||.:::    ::.::     :||.||
Zfish   476 AHLRTESYKMPWYSYHSVDVILVLISAVSLII----LSIYAVIRYFCCRICMR-----TTKNKR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	141/475 (30%)
ugt5b3	NP_001348442.1	UDPGT	27..531	CDD:278624	149/519 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584549
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790