DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt2a3

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001170814.2	Gene:	ugt2a3 / 100384900	ZFINID:	ZDB-GENE-080721-22	Length:	532	Species:	Danio rerio

Alignment Length:	546	Identity:	153/546 - (28%)
Similarity:	261/546 - (47%)	Gaps:	53/546 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LILGLLCSLGYSSGYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKPIPGYTDVS 70
            |:..|||  |...|::..:::.....||::...|:.:.||...|::||         :.|.:..:
Zfish     7 LVCLLLC--GVDVGWSGRVLVMPGEYSHWHNMRAIIEALVDRNHSVTV---------LVGSSSPT 60

  Fly    71 VPNV------------------IEVMGGDIGALWASIQKTYTQNLIDHYQMGFR-------ITRG 110
            ||:.                  .:.:..|...||.:...|..:.:.:.:|:..|       :.:|
Zfish    61 VPHTQKARFDYHVFKVNIEKEEADAVWSDFIYLWMNETATKYETVSNIFQVMSRFMTLTDEVCKG 125

  Fly   111 LFEDSNFQDFLKSNQSFDAIICETFY--NDAHYGLAEHFNAPLI-GLATGGGLTFITDMVGS-PA 171
            :|::...|...:|:  :|.:..:...  :|.   :|:..|.||: .|......:| ..|.|. ||
Zfish   126 MFKEDLLQMLRESH--YDVLFSDPMMPCSDL---MAQTLNIPLVLSLRATFAYSF-ERMCGQMPA 184

  Fly   172 PASFVPHIML--PFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRR 234
            |.|:||...|  ...|.||..||:.|:.......|....|.:.|.:::|.| ..|......:...
Zfish   185 PPSYVPAASLRDHLTDRMSFMERVENMLLYFSHDVFFKLYMMFTFDRIYTE-IRGKPTTMCETMG 248

  Fly   235 NASLVLINQHVSLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKT 298
            .|.:.||..:....:|||..||...|||:|.... .||.:::|.|:..| :||.:.||:||.:
Zfish   249 KADIWLIRTYWDFEYPRPFPPNFKFVGGLHCKPA-KPLSKEMEEFVQSSGDHGVVVFSLGSMI-- 310

  Fly   299 KDLPPSKVQEILKALGGLKQRVLWKFELDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGML 363
            |:|...:...|..|||.:.|:|:|::..........|..|.||.||.|:|.|||..||:||||..
Zfish   311 KNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTN 375

  Fly   364 STTESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQ 428
            ...|:|||..|::|||:|:||..|:.|.:..|..::||..||.:.:...|::.:.:.|||.:.:.
Zfish   376 GLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVLNNPSYKESIM 440

  Fly   429 GISFRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFVVMVLLLIVL 493
            .:|..:.||...|::.|:||:|.|.|::||.:|:..|..|:|:|||.:||...:..:..|:..:.
Zfish   441 RLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSIAALITFLW 505

  Fly   494 PITIYKLLKKLLLKGERTQSTKVKRN 519
            ......|.::.:.|....:.|:..:|
Zfish   506 VKACCFLFRRCVRKTRPERKTQKSKN 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	148/505 (29%)
ugt2a3	NP_001170814.2	UDPGT	21..519	CDD:278624	144/516 (28%)
		REC	<129..>178	CDD:302758	10/54 (19%)
		egt	<254..485	CDD:223071	86/233 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585039
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930