DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt302K1 and ugt5e1

DIOPT Version :9

Sequence 1:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_005166829.1	Gene:	ugt5e1 / 100002993	ZFINID:	ZDB-GENE-081105-106	Length:	590	Species:	Danio rerio

Alignment Length:	534	Identity:	152/534 - (28%)
Similarity:	257/534 - (48%)	Gaps:	71/534 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LNSAGR--------SHFNVGHALAKGLVKAGHTITVV----------------SVFPQKKPI--- 63
            |:.||:        ||:...:.|.:.|.:.||.:|||                |:..|...:
Zfish    78 LSLAGKILVYPVDGSHWLNMNILLQELHQRGHKLTVVRSANSWYIPENATHYTSITIQVNHLSSL 142

  Fly    64 --PGYTDVSVPNVIEVMGGDIGALWA--SIQKTYTQNLIDHYQMGFRITRGLFEDSNFQDFLKSN 124
              |.|....:...|::..|. |::|:  ::||.....|.:.::....:.|.:.||......||.:
Zfish   143 EDPKYMASFLKRNIDIQRGK-GSIWSFLALQKEIITLLEESHRSTAEMVRVVLEDEKLIKTLKES 206

  Fly   125 QSFDAIICETFYN-----DAHYGLAEHFNAPLIGLATGGGLTFITDMVG----SPAPASFVPHIM 180
            : :|.::.:..:.     .|:.||...||           :.:||:..|    :|:|.|::|.|.
Zfish   207 K-YDLMLTDPGFAGGVILGAYLGLPMVFN-----------VRWITNAEGHFAIAPSPLSYIPTIG 259

  Fly   181 LPFNDHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKEFFPGNKRCFYKMRRNASLVLINQHV 245
            ....|.||...:|.|:...|..:.:......|..:.:..::...|.. .|.:.:.|.|.|:....
Zfish   260 SRVTDKMSFANKLKNIMHFGIGQYIDHMLTRPLYQGVISKYIDPNTN-VYALIQGADLWLMRVDF 323

  Fly   246 SLSFPRPHSPNMIEVGGMHIDGKWNPLPEKIERFINES-EHGAIYFSMGSNLKTKDLPPSKVQEI 309
            ...||||..||::.:||...... .|||:::.:|:..| |||.:..|:|:.|.:  |.|...:.:
Zfish   324 VFEFPRPTMPNVVYIGGFQCKPS-KPLPDELNKFVESSGEHGVVIMSLGTLLGS--LVPDISEIV 385

  Fly   310 LKALGGLKQRVLWKFELDNLPNKP----ENVYISDWFPQTDILAHPKIMAFVTHGGMLSTTESIY 370
            ..|...|.|:|:|:    ::..||    .|..:.||.||.|:|.|||..|||||||.....|:||
Zfish   386 ASAFAQLPQKVIWR----HVGEKPSTLGNNTLVVDWLPQNDLLGHPKTKAFVTHGGTNGIYEAIY 446

  Fly   371 HAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSE-PSYTKVVQGISFRY 434
            |..|::|||:..|||.|:...|..|...|||..||:.....:|::.|..| .||.|.::.:|..:
Zfish   447 HGVPMLGLPLIFDQFDNIIRLEARGVARMLDVATLDVDILTQALKDILDEKQSYQKNMRKMSSLH 511

  Fly   435 RDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFVVM----VLLLIVLPI 495
            ||....|:::||:|:|.|.||:|||:|::.:.:|.|:.||.:|||.:|..:.    :||:::...
Zfish   512 RDTPLKPLDSAIFWLEFVMRHKGAAHLRTESYKLPWYSYHCLDVLALIMSLCTAAGLLLILISRA 576

  Fly   496 TIYKLLKKLLLKGE 509
            .:...::|:..|.|
Zfish   577 LLRACVRKIKAKKE 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	145/499 (29%)
ugt5e1	XP_005166829.1	UDPGT	82..586	CDD:278624	148/524 (28%)
ugt5e1	XP_005166829.1	egt	<324..550	CDD:223071	87/232 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584415
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790