DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt304A1 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	563	Identity:	146/563 - (25%)
Similarity:	242/563 - (42%)	Gaps:	133/563 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLPMFWLISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVI------------- 59
            ||....|....:.|  |.|:||:....||...|  .|.|:||.|:.|.:||:
Zfish     6 LLVCLLLCGVDVGW--SGRVLVMPGEYSHWHNM--RPVIEALVDKNHSVTVLVGSSSPTVPHTQK 66

  Fly    60 -----HAYKHCMHKIEDVTFIR-------------------IWYNNNVFLEFEE-------SVGI 93
                 |.:|..|.|.|....:|                   :|...:.|:||.:       .||:
Zfish    67 ERFEYHVFKVNMEKEEADAAMRDMIHLFTNDTAAKYEGEFVMWKVMSKFVEFGDVYFRGLFDVGL 131

  Fly    94 ASA--NNKWEEISS-----MSSLMANATLNVLNNVEVRALMKSRITFDAVVLEAGYSDVLYGMAA 151
            ...  ::.::.:.|     .|.|||. .||:...:.:||      ||                 |
Zfish   132 LKTLRDSNYDVLFSDPMMPFSDLMAQ-KLNIPQVISMRA------TF-----------------A 172

  Fly   152 HFSAQLIGICTCVADWNINNLVGFSTSTLTEPIMPFRAKYVKNV------------WDRIYNWLY 204
            :.:.:|.|                        .||....||..|            .:|:.|.|.
Zfish   173 YAAERLCG------------------------QMPAPPSYVPAVALTDHLTDRMSFMERVENMLL 213

  Fly   205 TTEEWLLINLVFLPKQRLIHDHFFGHL---EKSFHEIRQDFALMLLNQHFSLFRARPNVPGMVEV 266
                :::.::.|........|.::..:   ..:..|......:.|:..::.....||..|....|
Zfish   214 ----YIVHSIAFPLVATFTFDGYYSEILGKPTTMCETMGKVDICLIRTYWDFEYPRPFPPNFKFV 274

  Fly   267 AGLHIPKEDPQLPSDLQVFIDEA-EHGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQRVIWKF 330
            .|||.....| |..:|:.|:..: :|||::||||  ...|:|..:....:......:||:|:|::
Zfish   275 GGLHCKPAKP-LSKELEEFVQSSGDHGVVVFSLG--SMIKNLTSERANTIAAALGQIPQKVVWRY 336

  Fly   331 DGES--TMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRN 393
            .|::  |::..|.||  ..:||..:|.||..|.||:|.|...:.||.|:..|::|||.|.||..|
Zfish   337 SGKTPETLAPNTKIY--DWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDN 399

  Fly   394 LEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYI 458
            |..:|.:|.|:.|:|:::..|:|.||:.:::|.|.|:||.:.:|:...|||:.|||.|:||.|::
Zfish   400 LLHIKTKGAAVVLDIHTMGSKDLVDALKAVVNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFV 464

  Fly   459 IRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFL 501
            :|.|||.|:::...:|..:.|:.||   :....||:...:.||
Zfish   465 MRNKGAKHLRVQAHELSWYQYHCLD---VAAFLLSITALITFL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	139/540 (26%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	114/471 (24%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	141/546 (26%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	83/240 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585031
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690