DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt304A1 and ugt5c2

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001038851.1	Gene:	ugt5c2 / 751669	ZFINID:	ZDB-GENE-060825-206	Length:	552	Species:	Danio rerio

Alignment Length:	537	Identity:	145/537 - (27%)
Similarity:	248/537 - (46%)	Gaps:	67/537 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PGRWLLPMFW----LISNSICWIRSSRILVIAPFE-SHSQCMLVTPYIQALKDRGHQLTVIHAYK 63
            |...:....|    .|..|:|  ...:||| ||.| ||...|.:  .|:||..:||.:.||....
Zfish    26 PNNMVSVSLWTTVITIFGSLC--DGGKILV-APLEGSHWVNMDI--LIKALHGQGHTVDVIRNAN 85

  Fly    64 HCMHKIEDVTFIRIWYNNN-------------VFLEFEESVG-----IASANNKWEEISSMSSLM 110
            ....|.....:..|...|.             ..:::|:..|     :....|.::.:.....::
Zfish    86 SWFIKENSTYYDTITIPNTKGWDEEFAADFVYKMIKYEKEKGSWLSIVRLYLNVFDAVKKTHEMV 150

  Fly   111 ANATLNVLNNVEVRALMKSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWNINNLVGF 175
            .....|:|::.|:..::..: .:|.::     :|.::|.....:.:|.........|.......|
Zfish   151 CQLITNILDSEEILKMLNEK-QYDLML-----TDPVWGTGIILAHKLKLPMVYNVRWTTTGEGHF 209

  Fly   176 STSTLTEPIMPFRAKYV----------KNVWDRIYNWLYTTEEWLLINLV---FLPKQ-RLIHDH 226
            .       |.|....|:          .:.:.|:.|:.:    :||::|.   |..|| :.|.|.
Zfish   210 D-------IAPSPMSYIPITGSGNTDRMSFFQRLKNYFF----YLLLDLQLSHFNVKQYQAICDK 263

  Fly   227 FFGHLEKSFHEIRQDFALMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEA-E 290
            :|.. ..:|||:.|...|.|:...|.....||.:|.::.:.|...|...| ||.||:.|:..: :
Zfish   264 YFTS-RVNFHELLQGADLWLMRVDFVFEFPRPTMPNIIYIGGFQCPPAKP-LPHDLEDFMQSSGD 326

  Fly   291 HGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILA 355
            ||||:.|||  ....:||......:...|..:||:|||::.|:...:|..:......:||:.:|.
Zfish   327 HGVIVMSLG--SLIGNLPENVTAEIAAAFARLPQKVIWRYTGKKPSTLSNNTLMVDWMPQKDLLG 389

  Fly   356 HPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAI 420
            ||..|:||||.|...|:||.|:..||:|:|.||||:.||..::..|.|..|:|..|....|..||
Zfish   390 HPKTKVFISHGGTNGVLEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKLLSIADLGENTLHAAI 454

  Fly   421 HSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNF 485
            ..:||||.||.:...:|...:|:|:.|||:||:|.|:::|:|||.|::....::..:.|:|:|
Zfish   455 QEVINEPSYRLNMHKLSHLHKDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVD-- 517

  Fly   486 IMVGSRLSLVVALVFLV 502
             :|.:..::|:.|.:.:
Zfish   518 -VVVTLFAVVLILTYCI 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	138/509 (27%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	112/435 (26%)
ugt5c2	NP_001038851.1	UDPGT	49..551	CDD:278624	140/512 (27%)
ugt5c2	NP_001038851.1	egt	<288..528	CDD:223071	87/245 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585103
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690