Protein Alignment Ugt304A1 and UGT2B17

DIOPT Version :10

• Sequence 1: NP_652619.1
• Gene: Ugt304A1 / 53501
• FlyBaseID: FBgn0040250
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_001068.1
• Gene: UGT2B17 / 7367
• HGNCID: 12547
• Length: 530
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 140/531 - (26%)
• Similarity: 255/531 - (48%)
• Gaps: 69/531 - (12%)

  Fly    18 SICWIRSSRILVIAPFESHSQC--MLVTP-----------YIQALKDRGHQLTV--------IHA 61
            |:.|:....::.::.:.|...|  :||.|           .::.|..|||::.|        ::|
Human     2 SLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSASILVNA 66

  Fly    62 YKHCMHKIEDVTFIRIWYNN--NVFLE-FEESVGIASANNKWEEISSMSSLM-----ANATL--- 115
            .|....|:| |....:..|:  :.|:: |:......|.|..|...|.:..|.     .|..|
Human    67 SKSSAIKLE-VYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEYSDYNIKLCED 130

  Fly   116 NVLNNVEVRALMKSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWNINNLVGFSTSTL 180
            .|||...:|.|.:|:  ||.::.:|      ........|:|:.|...   :::...||::....
Human   131 AVLNKKLMRKLQESK--FDVLLADA------VNPCGELLAELLNIPFL---YSLRFSVGYTVEKN 184

  Fly   181 TEPIMPFRAKYVKNV----------WDRIYNWLYTTEEWLLINLVFLPKQRLIHDHFFGHL---E 232
            ....: |...||..|          .:||.|.:|    .|..:..|........|.|:..:   .
Human   185 GGGFL-FPPSYVPVVMSELSDQMIFMERIKNMIY----MLYFDFWFQAYDLKKWDQFYSEVLGRP 244

  Fly   233 KSFHEIRQDFALMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEA-EHGVILF 296
            .:..|......:.|:..::.....||.:|.:..|.|||.....| ||.:::.|:..: |:|:::|
Human   245 TTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKP-LPKEMEEFVQSSGENGIVVF 308

  Fly   297 SLGLEQDSKDLPRKTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKL 361
            |||  ....::..::..::......:||:|:|:|||:...:||::....|.|||..:|.||..|.
Human   309 SLG--SMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKA 371

  Fly   362 FISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINE 426
            ||:|.|...:.||.|:..|::|:|.|.||..|:..||.:|.||.::|.:::.::|.:|:.|:||:
Human   372 FITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVIND 436

  Fly   427 PEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSR 491
            |.|:|:.:.:|:...|||:.|||.|::|.|:::|:|||.|::::...|....|:|||   ::...
Human   437 PIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLD---VIAFL 498

  Fly   492 LSLVVALVFLV 502
            |:.|..::|::
Human   499 LACVATMIFMI 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	GT1_Gtf-like	26..454	CDD:340817	123/473 (26%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	136/509 (27%)