Protein Alignment Ugt304A1 and UGT2B15

DIOPT Version :10

• Sequence 1: NP_652619.1
• Gene: Ugt304A1 / 53501
• FlyBaseID: FBgn0040250
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_001067.2
• Gene: UGT2B15 / 7366
• HGNCID: 12546
• Length: 530
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 138/543 - (25%)
• Similarity: 261/543 - (48%)
• Gaps: 83/543 - (15%)

  Fly     6 RWLLPMFWLISNSICWIRSSRI--LVIAPFESHSQCMLVTPYIQALKDRGHQLTV--------IH 60
            :| ..:|.||..| |:..|...  :::.|.| :|..:.:...::.|..|||::||        ::
Human     4 KW-TSVFLLIQLS-CYFSSGSCGKVLVWPTE-YSHWINMKTILEELVQRGHEVTVLTSSASTLVN 65

  Fly    61 AYKHCMHKIE--DVTFIRIWYNNNVFLEFEESVGIASANNKWEEISSMSSL------MANATLN- 116
            |.|....|:|  ..:..:.:..:::....:..:...|.|..|...|.:..|      .:|....
Human    66 ASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEYYDYSNKLCKD 130

  Fly   117 -VLNNVEVRALMKSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWNINNLVGFS---- 176
             |||...:..|.:|:  ||.::.:|      ........|:|..|...   :::...||::
Human   131 AVLNKKLMMKLQESK--FDVILADA------LNPCGELLAELFNIPFL---YSLRFSVGYTFEKN 184

  Fly   177 --------------TSTLTEPIMPFRAKYVKNVWDRIY--NW--LYTTEEWLLINLVFLPKQRLI 223
                          .|.|::. |.|..: :||:...:|  .|  :|..::|
Human   185 GGGFLFPPSYVPVVMSELSDQ-MIFMER-IKNMIHMLYFDFWFQIYDLKKW-------------- 233

  Fly   224 HDHFFGHL---EKSFHEIRQDFALMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVF 285
             |.|:..:   ..:..|......:.|:..::.....||.:|.:..|.|||.....| ||.:::.|
Human   234 -DQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKP-LPKEMEEF 296

  Fly   286 IDEA-EHGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLP 349
            :..: |:|:::||||  ....::..::..::......:||:|:|:|||:...:||::....|.||
Human   297 VQSSGENGIVVFSLG--SMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLP 359

  Fly   350 QQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVK 414
            |..:|.||..|.||:|.|...:.||.|:..|::|:|.|.||..|:..||.:|.||.::|.:::.:
Human   360 QNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSR 424

  Fly   415 ELKDAIHSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDY 479
            :|.:|:.|:||:|.|:|:.:.:|:...|||:.|||.|::|.|:::|:|||.|::::...|....|
Human   425 DLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQY 489

  Fly   480 YSLDNFIMVGSRLSLVVALVFLV 502
            :|||   ::...|:.|..::|::
Human   490 HSLD---VIAFLLACVATVIFII 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	GT1_Gtf-like	26..454	CDD:340817	116/473 (25%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	131/521 (25%)