Protein Alignment Ugt304A1 and UGT2B10

DIOPT Version :9

• Sequence 1: NP_652619.1
• Gene: Ugt304A1 / 53501
• FlyBaseID: FBgn0040250
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_001066.1
• Gene: UGT2B10 / 7365
• HGNCID: 12544
• Length: 528
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 133/539 - (24%)
• Similarity: 259/539 - (48%)
• Gaps: 77/539 - (14%)

  Fly     6 RW----LLPMFWLISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCM 66
            :|    |:.:.:..|:..|    .::||.|  ..:|..|.:...::.|..|||::||:.:....:
Human     4 KWTTVLLIQLSFYFSSGSC----GKVLVWA--AEYSLWMNMKTILKELVQRGHEVTVLASSASIL 62

  Fly    67 HKIEDVTFIRIWYN---------NNVFLEFEESVGIASANNKW-------EEISSMSSLMANATL 115
            ....|.:.:::...         .|:.::..:.:.....:..|       |.:.:::.::.|...
Human    63 FDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAINDIIRNFCK 127

  Fly   116 NVLNNVE-VRALMKSRITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWNI---------- 169
            :|::|.: ::.|.:||  ||.|..:|      |.......|:|         :||
Human   128 DVVSNKKLMKKLQESR--FDIVFADA------YLPCGELLAEL---------FNIPFVYSHSFSP 175

  Fly   170 -----NNLVGFSTSTLTEPIMPFRAKYVKNVWDRIYNWLYTT--EEWLLINLVFLPKQRLIHDHF 227
                 .:..||.......|::..:........:|:.|.||..  :.|..|   |..|:   .|.|
Human   176 GYSFERHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQI---FNMKK---WDQF 234

  Fly   228 FGHL---EKSFHEIRQDFALMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEA 289
            :..:   ..:..|..:...:.|:...::.....|.:|.:..|.|||.....| ||.:::.|:..:
Human   235 YSEVLGRPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKP-LPKEMEEFVQSS 298

  Fly   290 -EHGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAI 353
             |:||::||||  ....::..:...::......:||:|:|:|||....:||.:....|.:||..:
Human   299 GENGVVVFSLG--SMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQNDL 361

  Fly   354 LAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKD 418
            |.||..:.||:|.|...:.||.|:..|::|:|.||||..|:..||.:|.|:.::.|:::..:|.:
Human   362 LGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMSSTDLLN 426

  Fly   419 AIHSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLD 483
            |:.::||:|.|:|:.:.:|:...|||:.|||.|::|.|:::|:|||.|::::...|..|.|:|||
Human   427 ALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWFQYHSLD 491

  Fly   484 NFIMVGSRLSLVVALVFLV 502
               ::|..|:.|..::|::
Human   492 ---VIGFLLACVATVLFII 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	124/509 (24%)
		YjiC	42..445	CDD:224732	102/440 (23%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	129/516 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150502
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.690