DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt304A1 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	526	Identity:	145/526 - (27%)
Similarity:	241/526 - (45%)	Gaps:	91/526 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCMHKIEDVTFIRIWYNNNVFLEFEES 90
            ::||.....||...|.|  .|:.|..:||.:||:.....             ||.... ..|..|
Zfish    23 KVLVFPLDGSHWVNMKV--LIEELHRKGHNVTVVRPSNS-------------WYIKEE-SPFYSS 71

  Fly    91 VGIASANNKWEEISSMSSLMANATLN-------VLNNV--EVRALMK------------SRITFD 134
            :.|.:.....||   .|.|:.|..|.       |||.|  |...:||            .|:..|
Zfish    72 ITIPNTGGFDEE---FSGLLINRLLEIKRGGYFVLNRVRLEFEIMMKFKTMHEDMLQMMDRMLED 133

  Fly   135 AVVL----EAGYSDVLYG--------MAAHFSAQLIGICTCVADWNINNLVGFSTS--------- 178
            ..|:    :|.:..||..        :|..|:..|:    ....|.|.....|:.:
Zfish   134 EKVMNSIQDAKFDVVLADPAVGGGPILAYKFNIPLV----FNVRWTIQGEGHFAIAPSPLSYIPV 194

  Fly   179 ---TLTEPIMPFRAKYVKNVWDRIYNWLYTTEEWLLINLVFLPKQRLIHDHFFGHLEKSFHEIRQ 240
               .||:. |.|..: ||||  .|| .:...:..:::..::.|   ..|.||..::  ::..:.|
Zfish   195 PGVELTDK-MSFLQR-VKNV--LIY-LISQIQMQIMVEPIYAP---FCHKHFGPNV--TYFSLFQ 249

  Fly   241 DFALMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEA-EHGVILFSLG--LEQ 302
            |..:.|:...|:....||.:|.:|.::|.......| ||:||:.|::.: |||||:.|||  :.|
Zfish   250 DADIWLMRNDFTFEFPRPTMPNIVYMSGFQCKPAKP-LPNDLEKFVESSGEHGVIVMSLGTLIAQ 313

  Fly   303 DSKDLPRKTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCG 367
                ||:...:.:...|..:||:|||::.|...::||.:....:.|||..:|.||.:|:|::|.|
Zfish   314 ----LPQDMTDDIAAAFAELPQKVIWRYTGPRPVTLGNNTLLVEWLPQNDLLGHPQIKVFVAHGG 374

  Fly   368 MMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRES 432
            ...:.||.|:..|:||||..|||..||..|:.:|.|..::|.:|......:|:..::..|.|||:
Zfish   375 TNGIQEAIYHGVPILGLPLVFDQPDNLFRMEAKGTAKIVDIATLDKTVFLEALKEVLYNPSYREN 439

  Fly   433 ALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVA 497
            ...:|:...|||:.|||.|::|.|:::|.|||.|::....::...:|:|:|..:.:     :|..
Zfish   440 MQRLSKLHHDQPLKPLDRAMFWIEFVMRNKGAPHLRTQSFRMSWIEYHSIDVILTL-----MVTG 499

  Fly   498 LVFLVL 503
            .||.::
Zfish   500 FVFALM 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	139/501 (28%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	122/450 (27%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	145/526 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584446
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690