DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	XP_038948318.1	Gene:	Ugt2a1 / 63867	RGDID:	69432	Length:	528	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	132/519 - (25%)
Similarity:	238/519 - (45%)	Gaps:	77/519 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCMHKIEDVTFIRIWYNNNVFLEFEESVG 92
            :||.|.:. |..:.:...::.|..|.|.:||:.|        .:..||.  .:.:.|:.||| :.
  Rat    24 VVIWPSDG-SHWLNIKILLEELVQRNHSVTVLAA--------SETLFIN--SSPDAFISFEE-IP 76

  Fly    93 IASANNK-------------------------WEEISSMSSLMANATLNVLNNVEVRALMKSRIT 132
            ::...:|                         ::|:..:.:........:.:.|...|.:.:|
  Rat    77 VSYTRSKIDEMIEHMIALWLDHRPTPLTMWAFYKELGKLFAAFYKINKQICDGVLKNATLMAR-- 139

  Fly   133 FDAVVLEAGYSDVLYG----MAAHFSAQLIGICTCVADWNINNLVGFSTSTLTE---PIMPFRAK 190
                 |:.|..|||..    |.....|..:||.....       :.||.:...|   ..:|....
  Rat   140 -----LQKGGFDVLISDPVTMCGELVALKLGIPFVYT-------LRFSPAFTVERHCGKIPTPVS 192

  Fly   191 YVKNVWDRIYNWLYTTEEWLLINLVFLPKQRLIHDHFFGHLEKSFH----------EIRQDFALM 245
            ||......:.:.:...|.  :.|.:....|..|...::|.....:.          |......:.
  Rat   193 YVPAALSELTDQMTFGER--VKNTISYSLQDYIFKSYWGEWNSYYSRVLGRPTTLCETMGKAEIW 255

  Fly   246 LLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFID-EAEHGVILFSLGLEQDSKDLPR 309
            |:..::.....||.:|....|.|||.....| ||.:::.|:. ..||||::||||  ...|:|..
  Rat   256 LMRTYWDFEFPRPYLPNFEFVGGLHCKPAKP-LPKEMEEFVQTSGEHGVVVFSLG--SMVKNLTE 317

  Fly   310 KTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEA 374
            :...::......:||:|:|::.|:...:||::......:||..:|.||..:.||:|.|...:.||
  Rat   318 EKANLIASALAQIPQKVLWRYKGKIPATLGSNTRLFDWIPQNDLLGHPKTRAFITHGGTNGIYEA 382

  Fly   375 AYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQR 439
            .|:..|::|:|.|.||..|:..||.:|.|:|:|:|::|..:|..|:.::||||.|:|:|:.:|:.
  Rat   383 IYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSADLLSAVRAVINEPFYKENAMRLSRI 447

  Fly   440 FRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFLVL 503
            ..|||:.|||.|::|.|:::|:|||.|::::...|..|.|:|||   ::|..|:.:.:.:.||:
  Rat   448 HHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLD---VIGFLLACMASAILLVI 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	124/494 (25%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	106/445 (24%)
Ugt2a1	XP_038948318.1	UDPGT	22..524	CDD:278624	132/519 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860