DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt304A1 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	537	Identity:	135/537 - (25%)
Similarity:	246/537 - (45%)	Gaps:	83/537 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 W--LLPMFWLISNSICWIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYK--HCMH 67
            |  ::|:|..:.:      ..:|||: |.|. |..:.:...|:||..:||.:.||....  :...
Zfish    14 WITIIPLFGFLCD------GGKILVV-PLEG-SHWLNMDILIKALHGKGHSIDVIRNTNSWYVKE 70

  Fly    68 KIEDVTFIRIWYNNNVFLEFEESVGIASANNKWEEISS-----------------MSSLMANATL 115
            |.:....|.|..:..:..||.:.: |:...|.....||                 |:.::.:.|.
Zfish    71 KSDYYNSITIPQSKGMDEEFVDDM-ISKVINHERGKSSWLSTVKLFFDSVIDNYEMTKMVCDITT 134

  Fly   116 NVLNNVEVRALMKSRITFDAVVLEAGYSDVLYGMA---AH-------FSAQLIGICTCVADWNIN 170
            ::..:.|:...::.: .:|.::     :|.::||.   ||       ::.:    .|...|.:.|
Zfish   135 SIFESEEILKTLQEK-QYDLML-----TDPVWGMGIILAHKLKLPMVYNVR----WTTTVDGHFN 189

  Fly   171 NLVGFSTSTLTEPIMPFRAKYV----------KNVWDRIYNWLYTTEEWLLINLVFLPKQRLIHD 225
                         |.|....|:          .:.:.|:.|.::.....:..:...||:.:.|.|
Zfish   190 -------------IAPSPMSYIPITGSGNTDRMSFFQRVKNIIFYFTNDIKYSRFSLPQYQAICD 241

  Fly   226 HFFGHLEKSFHEIRQDFALMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEA- 289
            .:|.. ...|:::.|...:.|:...|.....||.:|.::...|.......| ||.||:.|:..:
Zfish   242 KYFDP-PVDFYQLLQGADIWLMRVDFVFEFPRPTMPNIIYTGGFQCTPAKP-LPHDLEDFMQSSG 304

  Fly   290 EHGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAIL 354
            :||||:.|||....:  ||......:...|..:||:|||::.|:...:||.:......:||:.:|
Zfish   305 DHGVIVMSLGTFISA--LPEDVTAEIAAAFARLPQKVIWRYTGKKPSTLGNNTLLVDWMPQKDLL 367

  Fly   355 AHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDA 419
            .||..|:|::|.|...|.||.|:..||:|:|.||||:.||..::..|.|..:::..|....|..|
Zfish   368 GHPKTKVFVAHGGTNGVQEALYHGVPVVGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAA 432

  Fly   420 IHSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDN 484
            |..:||.|.||.:...:||...|:|:.|||:||:|.|:::|:|||.|::....::..:.|:|:|.
Zfish   433 IKEVINNPSYRLTMQKLSQLHLDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDV 497

  Fly   485 FIMVGSRLSLVVALVFL 501
            .:.:     :.|.|:|:
Zfish   498 AVTL-----IAVVLIFI 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	128/511 (25%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	107/442 (24%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	132/517 (26%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	82/247 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585104
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.690