DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt304A1 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	531	Identity:	142/531 - (26%)
Similarity:	252/531 - (47%)	Gaps:	77/531 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 CWIRSSRILVIAPFE-SHSQCMLVTP-----------YIQALKDRGHQLTVIHAYKHCMHKIEDV 72
            |.::.|.:::|..|. :|:..:||.|           .:..|.:|.|.:||:     .......:
Zfish     4 CLLKPSPLVLIFIFSFTHAGNVLVLPGEYSHWQNMRNVVDELLNRNHTVTVL-----VCSASPTI 63

  Fly    73 TFIRIWYNNNVFLEFEESVGIASANNK-------WEEISSMSSLM-ANATLNVLNNVEV--RALM 127
            .|.:  .....:|.||..:.....:..       |.:..|.:.|. |...:.:|..|.|  ||:.
Zfish    64 NFTQ--QERFQYLVFEVPLSAQELDGASEELIHIWTQHPSPNRLQTALQIIELLGRVRVMHRAMC 126

  Fly   128 KSRITFDAVV--LEAGYSDVLYG----MAAHFSAQLIGICTCVADWNINNLVGF----------- 175
            .|.:..||::  |.|...|||:.    |.|...|:::|:...:   ::....||
Zfish   127 DSMLRNDALIAQLSALKFDVLFNDPMFMCADLLAEMLGLPLVL---SVRISPGFCLERMCGQMPA 188

  Fly   176 --STSTLTEPIMPFRAKYVKNVWDRIYNWLYTTEEWLL--INLVFLPKQRLIHDHFFGHL---EK 233
              |...:|:.::..|..:::.|.:.|.|.:::...:::  |:|          |.::..:   ..
Zfish   189 PPSFVPITQTVLTDRMCFMERVQNMIANIVFSVSFYIVAWISL----------DSYYTDVLGKPT 243

  Fly   234 SFHEIRQDFALMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEA-EHGVILFS 297
            :..|......:.|:..::.....||..|....|.|||.....| |..:::.|:..: :|||::||
Zfish   244 TMCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLHCKPAKP-LSKEMEEFVQSSGDHGVVVFS 307

  Fly   298 LGLEQDSKDLPRKTQEILVETFKSVPQRVIWKFDGES--TMSLGTDIYHSKLLPQQAILAHPNVK 360
            ||  ...|:|..:....:......:||:|:|::.|::  |::..|.||  ..:||..:|.||..|
Zfish   308 LG--SMIKNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIY--DWIPQNDLLGHPKTK 368

  Fly   361 LFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMIN 425
            .||:|.|...:.||.|:..|::|||.|.||..||..||.:|.|:.|:||:|..|:|.||:.:::|
Zfish   369 AFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVLN 433

  Fly   426 EPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGS 490
            .|.|:||.:.:|:...|||:.|||.|:||.|:::|.|||.|:::...:|..:.|:.||   :...
Zfish   434 NPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLD---VAAF 495

  Fly   491 RLSLVVALVFL 501
            .||:...:.||
Zfish   496 LLSIAALITFL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	135/508 (27%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	115/450 (26%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	137/512 (27%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	85/235 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860