Protein Alignment Ugt304A1 and UGT1A4

DIOPT Version :10

• Sequence 1: NP_652619.1
• Gene: Ugt304A1 / 53501
• FlyBaseID: FBgn0040250
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_009051.1
• Gene: UGT1A4 / 54657
• HGNCID: 12536
• Length: 534
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 127/513 - (24%)
• Similarity: 239/513 - (46%)
• Gaps: 63/513 - (12%)

  Fly    21 WIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCMHKIEDVTFIRI------WY 79
            |..|.::||: |.:. |..:.:...::.|..||||..|:....: || |::..|..:      |.
Human    25 WAESGKVLVV-PTDG-SPWLSMREALRELHARGHQAVVLTPEVN-MH-IKEEKFFTLTAYAVPWT 85

  Fly    80 NNNVFLEFEE-----SVGIASANNKWEEISSMSSLMANATL-------NVLNNVEVRALMK--SR 130
            ..    ||:.     :.|.....:..:..|...::|.|.:|       .:|:|   .||::  :.
Human    86 QK----EFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNVSLALHRCCVELLHN---EALIRHLNA 143

  Fly   131 ITFDAVVLEAGYSDVLYGMAAHFSAQLIGICTCVADWN-INNLVGFSTSTLTEPIMPFRAKYVKN 194
            .:||.|:.:.      ..:.....|:.:.| ..|..|. |...:.|..:....|     :.|:..
Human   144 TSFDVVLTDP------VNLCGAVLAKYLSI-PAVFFWRYIPCDLDFKGTQCPNP-----SSYIPK 196

  Fly   195 V----------WDRIYNWLYTTEEWLLINLVFLPKQRLIHDHFFGHLEKSFHEIRQDFALMLLNQ 249
            :          ..|:.|.||......:.:....|...|..:.|  ..|.|..::....::.|...
Human   197 LLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELF--QREVSVVDLVSYASVWLFRG 259

  Fly   250 HFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFID-EAEHGVILFSLGLEQDSKDLPRKTQE 313
            .|.:...||.:|.||.:.|::.....| |..:.:.:|: ..|||:::||||  ....::|.|...
Human   260 DFVMDYPRPIMPNMVFIGGINCANGKP-LSQEFEAYINASGEHGIVVFSLG--SMVSEIPEKKAM 321

  Fly   314 ILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYYA 378
            .:.:....:||.|:|::.|....:|..:....|.|||..:|.||..:.||:|.|...|.|:....
Human   322 AIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNG 386

  Fly   379 KPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFRDQ 443
            .|::.:|.|.||..|.:.|:.:|..:.||:..:|.::|::|:.::||:..|:|:.:.:|...:|:
Human   387 VPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDR 451

  Fly   444 PIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFL 501
            |:.|||.|::|.|:::|:|||.|::.:...|..:.|:|||   ::|..|::|:.:.|:
Human   452 PVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLD---VIGFLLAVVLTVAFI 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	GT1_Gtf-like	26..454	CDD:340817	109/459 (24%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	125/509 (25%)