Protein Alignment Ugt304A1 and UGT1A6

DIOPT Version :9

• Sequence 1: NP_652619.1
• Gene: Ugt304A1 / 53501
• FlyBaseID: FBgn0040250
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 138/549 - (25%)
• Similarity: 246/549 - (44%)
• Gaps: 103/549 - (18%)

  Fly     8 LLPMFWLISNSI----CW--IRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVI------- 59
            ||..|..||..:    .|  :...::||:....||  .:.:...::.|.||||::.|:
Human     4 LLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSH--WLSMKDIVEVLSDRGHEIVVVVPEVNLL 66

  Fly    60 -HAYKHCMHKIEDVTFIRIWYNNNVFLEFEESVGIASANNKWEEISSMSSLMANATLNV----LN 119
             ...|:...||..|.     |:........:|.|    ||.:.|.|.:::.......|:    |.
Human    67 LKESKYYTRKIYPVP-----YDQEELKNRYQSFG----NNHFAERSFLTAPQTEYRNNMIVIGLY 122

  Fly   120 NVEVRALMKSRIT--------FDAV---------VLEAGYSDVLYGMAAHFSAQLIGICTCVADW 167
            .:..::|::.|.|        |||:         |:.|.|    .|:.   |..|.....|..:.
Human   123 FINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEY----LGLP---SVYLFRGFPCSLEH 180

  Fly   168 NINNLVGFSTSTLTEPIMPFRAKYVK-----NVWDRIYNWLYTTEEWLLINLVFLPKQRLIHDHF 227
            .      ||.|  .:|:......|.|     ....|:.|:        |:|        |:..:.
Human   181 T------FSRS--PDPVSYIPRCYTKFSDHMTFSQRVANF--------LVN--------LLEPYL 221

  Fly   228 FGHLEKSFHEIR--------------QDFALMLLNQHFSLFRARPNVPGMVEVAGLHIPKEDPQL 278
            |..|...:.|:.              |..::.||...|.|...||.:|.||.:.|::. |:...|
Human   222 FYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINC-KKRKDL 285

  Fly   279 PSDLQVFID-EAEHGVILFSLGLEQDSKDLPRKTQEILVETFKSVPQRVIWKFDGESTMSLGTDI 342
            ..:.:.:|: ..|||:::||||  ....::|.|....:.:....:||.|:|::.|....:|..:.
Human   286 SQEFEAYINASGEHGIVVFSLG--SMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNT 348

  Fly   343 YHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLGLPSFFDQFRNLEIMKEEGVALELN 407
            ...|.|||..:|.||..:.||:|.|...|.|:.....|::.:|.|.||..|.:.|:.:|..:.||
Human   349 ILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLN 413

  Fly   408 INSLTVKELKDAIHSMINEPEYRESALAISQRFRDQPIHPLDAAIYWTEYIIRYKGADHMKISQS 472
            :..:|.::|::|:.::||:..|:|:.:.:|...:|:|:.|||.|::|.|:::|:|||.|::.:..
Human   414 VLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH 478

  Fly   473 QLKLFDYYSLDNFIMVGSRLSLVVALVFL 501
            .|..:.|:|||   ::|..|::|:.:.|:
Human   479 DLTWYQYHSLD---VIGFLLAVVLTVAFI 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	130/526 (25%)
		YjiC	42..445	CDD:224732	107/451 (24%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	133/538 (25%)
		UDPGT	27..523	CDD:278624	132/526 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150652
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.690