Protein Alignment Ugt304A1 and UGT2B28

DIOPT Version :10

• Sequence 1: NP_652619.1
• Gene: Ugt304A1 / 53501
• FlyBaseID: FBgn0040250
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_444267.1
• Gene: UGT2B28 / 54490
• HGNCID: 13479
• Length: 529
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 129/516 - (25%)
• Similarity: 243/516 - (47%)
• Gaps: 56/516 - (10%)

  Fly    20 CWIRS---SRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAYKHCMHKIEDVTFIR--IWY 79
            |:..|   .::||.....||  .|.:...::.|..|||::||:.:....:....|...::  ::.
Human    16 CYFSSGSCGKVLVWTGEYSH--WMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYP 78

  Fly    80 NNNVFLEFEESVGIASANNKWEEISSMS----------------SLMANATLNVLNNVEV-RALM 127
            .:....|||..  |.....:|.:|...|                .:..|...:|::|.:| :.|.
Human    79 TSLTKTEFENI--IMQQVKRWSDIQKDSFWLYFSQEQEILWEFHDIFRNFCKDVVSNKKVMKKLQ 141

  Fly   128 KSRITFDAVVLEAGYSDVLYG----MAAHFSAQLIGICTCVADWNINNLVG---FSTSTLTEPIM 185
            :||  ||.:     ::|..:.    :||..:...:........:.|....|   |..|.:  |::
Human   142 ESR--FDII-----FADAFFPCGELLAALLNIPFVYSLCFTPGYTIERHSGGLIFPPSYI--PVV 197

  Fly   186 PFRAKYVKNVWDRIYNWLYTTEEWLLINLVFLPKQRLIHDHFFGHL---EKSFHEIRQDFALMLL 247
            ..:........:|:.|.:|.    |..:..|........|.|:..:   ..:..|......:.|:
Human   198 MSKLSDQMTFMERVKNMIYV----LYFDFWFQMCDMKKWDQFYSEVLGRPTTLFETMGKADIWLM 258

  Fly   248 NQHFSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEA-EHGVILFSLGLEQDSKDLPRKT 311
            ...:|.....|.:|.:..|.|||.....| ||.:::.|:..: |:||::||||  ....::..:.
Human   259 RNSWSFQFPHPFLPNIDFVGGLHCKPAKP-LPKEMEEFVQSSGENGVVVFSLG--SVISNMTAER 320

  Fly   312 QEILVETFKSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAY 376
            ..::......:||:|:|:|||....:||.:....|.:||..:|..|..:.||:|.|...:.||.|
Human   321 ANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQNDLLGLPKTRAFITHGGANGIYEAIY 385

  Fly   377 YAKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFR 441
            :..|::|:|.|:||..|:..||.:|.|:.|:.::::..:|.:|:.::||:|.|:|:.:.:|....
Human   386 HGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTMSSTDLLNALKTVINDPSYKENVMKLSIIQH 450

  Fly   442 DQPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFLV 502
            |||:.||..|::|.|:::.:|||.|::::...|..|.|:|||   ::|..|:.|..::|:|
Human   451 DQPVKPLHRAVFWIEFVMCHKGAKHLRVAARDLTWFQYHSLD---VIGFLLACVATVIFVV 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	GT1_Gtf-like	26..454	CDD:340817	110/457 (24%)
UGT2B28	NP_444267.1	UDPGT	24..525	CDD:278624	127/508 (25%)