DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt304A1 and Ugt37E1

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	157/526 - (29%)
Similarity:	246/526 - (46%)	Gaps:	75/526 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VIAPFESHSQCMLVT--PYIQALKDRGHQLTVIHAYKHCMHKIEDVTFI-------RIWYNNNVF 84
            ::..|.:||...::.  ..::||.||||.:||:...|..:...|::|.|       |..|.....
  Fly    27 ILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATHENITVIIAPPTEERQRYIKEYM 91

  Fly    85 LEFEESVGIASANNK---WEEISS---MSSLMANATLNVLNNVEVRALMKS-RITFDAVVLEAGY 142
            .|.        :|.|   ||.:..   .||.........:.:..|:.:.:: :|.||.|.|....
  Fly    92 AEV--------SNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPNVKEIYENPKIKFDLVFLGLMA 148

  Fly   143 SDVLYGMAAHFSAQLIGICTCVADWNINNLVGFSTSTLTEPIMPFRAKYVKNVWDRIY------- 200
            :....|:||...      |..:..|     ||..        :||....|.||.|..|
  Fly   149 NTYQLGIAAKLK------CPVIISW-----VGIP--------LPFMDTIVGNVNDPSYVPTVNVA 194

  Fly   201 -NWLYTTEEWLL---------INLVFLP----KQRLIHDHFFGH-LE-KSFHEIRQDFALMLLNQ 249
             |....|.::.|         |..||..    |....::..|.: || .::||:::..:|:..|.
  Fly   195 LNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERAFANELEFPNYHEMKRRVSLLFYNY 259

  Fly   250 H-FSLFRARPNVPGMVEVAGLHIPKEDPQLPSDLQVFIDEAEHGVILFSLGLEQDSKDLPRKTQE 313
            | .|....||.||..:|:.|:.:.::...||.:|..|:|:|:.|.|.||||...::......|.:
  Fly   260 HSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADEGAIFFSLGTNVNTNTFRPDTVD 324

  Fly   314 ILVETFKSVPQRVIWKF-DGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYY 377
            ||.:....:|||||||: |.::.....::|:....|||..||||||.||||:|.|...|.||.|:
  Fly   325 ILYKVLSKLPQRVIWKWEDLKNKPGNASNIFFGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYH 389

  Fly   378 AKPVLGLPSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFRD 442
            ..|::.||.|.||..|.|||.:.|....|:|.::|..||:..|..::..|.|||:....|..:||
  Fly   390 GVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPAYRETIGKFSTLYRD 454

  Fly   443 QPIHPLDAAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFLVLSK-- 505
            :|:....:.||||||::|::||.|:   ||.|....:.:.:|..:.|  :.|:|:|:.:|..|
  Fly   455 RPLTARQSVIYWTEYVLRHQGALHL---QSPLIHTKFVARNNLDVYG--VVLLVSLLLIVTIKFL 514

  Fly   506 SRRWLN 511
            .|:.||
  Fly   515 FRKILN 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	147/491 (30%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	130/443 (29%)
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	141/474 (30%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	130/447 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445758
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.850