DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt304A1 and Ugt35E1

DIOPT Version :9

Sequence 1:	NP_652619.1	Gene:	Ugt304A1 / 53501	FlyBaseID:	FBgn0040250	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	179/509 - (35%)
Similarity:	279/509 - (54%)	Gaps:	54/509 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WIRSSRILVIAPFESHSQCMLVTPYIQALKDRGHQLTVIHAY--KHCMHKIEDVTFIRIWYNNNV 83
            ::..:|||.:.|..|||......||::.|...||::|.:..:  :..:..|.|:      |...|
  Fly    17 FLYGARILALFPVPSHSHYYHALPYLKNLASLGHEITSVSPFPSEEPVKNIYDI------YVPEV 75

  Fly    84 FLEFEESV-GIASANNKWEEISSMSSLMANATLNVLNNVEVR--ALMKSRITFDAVVLEAGYSDV 145
            ...|:|.: .:.:..|.||...:.:..:.|.|.:|.||..||  .|...:..||.::::....|.
  Fly    76 LNSFDELLKQMTTPKNTWEFFDATNEFVYNITKDVFNNDGVRREILRPGKAQFDLIIVDIWKYDA 140

  Fly   146 LYGMAAHFSAQLIGICTCVADWNINNLVGFST--STLTEPIMPFRAKYVKNV------------- 195
            .|.:||:|.|.:||:..|..||.|:.:||..:  |.|..|     :.|:.|:
  Fly   141 FYSLAAYFEAPIIGLAPCGIDWKIDEMVGNPSPMSYLQSP-----SSYLYNLDTFGGRVAHVVEV 200

  Fly   196 ---WDRIYNWLYTTEEWLLINLVFLPKQRLIHDHFFGHL--EKSFHEIRQDFALMLLNQHFSLFR 255
               |   :||.:..|:          |...::..:|..:  .|...||.||.||:|:||||:|..
  Fly   201 AISW---FNWHWRYEQ----------KHEALYKKYFPKIAETKPLSEISQDIALVLVNQHFTLGP 252

  Fly   256 ARPNVPGMVEVAGLHIPKEDPQLPSDLQVFID-EAEHGVILFSLGLEQDSKDLPRKTQEILVETF 319
            .||.||.::||.|:||.::...|..||:.||. ..|||||.||||....:|::....:.||:|.|
  Fly   253 PRPYVPNVIEVGGMHIDEQPKALAQDLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAF 317

  Fly   320 KSVPQRVIWKFDGESTMSLGTDIYHSKLLPQQAILAHPNVKLFISHCGMMSVIEAAYYAKPVLGL 384
            .|:||||:|||:.|....:.:::...|.||||.:||||.|||||:|.||.|.||:.:|.||:|||
  Fly   318 GSLPQRVLWKFEDEELQDIPSNVLVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGL 382

  Fly   385 PSFFDQFRNLEIMKEEGVALELNINSLTVKELKDAIHSMINEPEYRESALAISQRFRDQPIHPLD 449
            |.|:|||.|::.:|:.|..|.||.:.:|..|||..|..::.|..:..:|.....|:||||:.||:
  Fly   383 PFFYDQFTNVDHIKKHGFCLSLNYHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLE 447

  Fly   450 AAIYWTEYIIRYKGADHMKISQSQLKLFDYYSLDNFIMVGSRLSLVVALVFLVL 503
            .|::||.|::|:|||.||:::..:|..|.::|||   ::|:.| ||:.||.:.:
  Fly   448 TAVWWTHYVLRHKGAPHMRVAGRKLSFFTHHSLD---VLGTVL-LVILLVIIAI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt304A1	NP_652619.1	egt	8..480	CDD:223071	170/484 (35%)
Ugt304A1	NP_652619.1	YjiC	42..445	CDD:224732	148/428 (35%)
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	163/467 (35%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	167/477 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445591
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.800